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Sodium Picosulfate BP Grade Manufacturers, SDS GHS MSDS Sheet

Sodium Picosulfate: CAS Number: 10040-45-6, EINECS EC Number: 233-120-9, Molecular Formula: C18H13NNa2O8S2, Molecular Weight: 499.42, HS Code ---**

For SDS MSDS Sheet Click
SDS MSDS Sheet of Sodium Picosulfate Manufacturers

Sodium Picosulfate
Pure BP Grade
Sodium picosulfate

Sodium Picosulfate BP

Ph Eur
C18H13NNa2O8S2,H2Oıı499.4ıı10040-45-6
(anhydrous)

Action and use: Stimulant laxative.

DEFINITION
Sodium picosulfate contains not less than 98.5 per cent and not more than the equivalent of 100.5 per cent of 4,4'-(pyridin-2-ylmethylene)bisphenyl bis(sodium sulphate), calculated with reference to the anhydrous substance.

CHARACTERS
A white or almost white, crystalline powder, freely soluble in water, slightly soluble in alcohol.

IDENTIFICATION
First identification A, E.
Second identification B, C, D, E.
A. Examine by infrared absorption spectrophotometry, comparing with the spectrum obtained with sodium picosulfate CRS. Examine the substances prepared as discs.
B. Examine the chromatograms obtained in the test for related substances in ultraviolet light
B. Examine the chromatograms obtained in the test for related substances in ultraviolet light at 254 nm. The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (a).
C. To 5 ml of solution S (see Tests) add 1 ml of dilute hydrochloric acid and heat to boiling. Add 1 ml of barium chloride solution. A white precipitate is formed.
D. To about 10 mg add 3 ml of sulphuric acid and 0.1 ml of potassium dichromate solution. A violet colour develops.
E. The solution S gives reaction (a) of sodium.

TESTS
Solution S: Dissolve 2.5 g in distilled water and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
Acidity or alkalinity: To 10 ml of solution S add 0.05 ml of phenolphthalein solution. The solution is colourless. Not more than 0.25 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.
Related substances: To pass the test.
Chlorides: Dilute 5 ml of solution S to 15 ml with water. The solution complies with the limit test for chlorides (200 ppm).
Sulphates: Dilute 7.5 ml of solution S to 15 ml with distilled water. The solution complies with the limit test for sulphates (400 ppm).
Heavy metals: 12 ml of solution S complies with limit test A for heavy metals (20 ppm). Prepare the standard using 10 ml of lead standard solution (1 ppm Pb).
Water: 3.0 per cent to 5.0 per cent, determined on 0.500 g by the semi-micro determination of water.

ASSAY
Dissolve 0.400 g in 80 ml of methanol. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically. 1 ml of 0.1 M perchloric acid is equivalent to 48.14 mg of C18H13NNa2O8S2.

IMPURITIES
Impurities in Sodium Picosulfate
A. R = SO3Na: 4-[(pyridin-2-yl)(4-hydroxyphenyl)methyl]phenyl sodium sulphate,
B. R = H: 4,4¢-[(pyridin-2-yl)methylene]bisphenol.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) 91-22-23770100, 23726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA & Canadian Customers may
e-mail: usa@mubychem.com
Call toll-free 1-844-682-9243 (1-844-MUBYCHEM)

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Last 16 August, 2017

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Sodium Picosulfate SDS MSDS Sheet, Material Safety Data Sheet

1. PRODUCT DESCRIPTION

Product Name: Sodium Picosulfate
CAS Number: 10040-45-6
EINECS EC Number: 233-120-9
Molecular Formula: C18H13NNa2O8S2
Molecular Weight: 499.42
Recommended usage
: Industrial Manufacturing.
Suppliers: As per letterhead.

2. HAZARD IDENTIFICATION

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according GHS & Regulation (EC) No 1272/2008

GHS Label Elements
None

Signal Words: None

Hazards not otherwise classified (HNOC):
May causes mild skin irritation.
May causes mild eye irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Product Name: Sodium Picosulfate
CAS Number: 10040-45-6
EINECS EC Number: 233-120-9
Weight Percent 100%

4. FIRST AID MEASURES

Always get medical attention after the first aid is over.

Emergency and First Aid Procedures:
Eyes - Flush with water for at least 15 minutes, raising and lowering eyelids occasionally. Get medical attention if irritation persists.
Skin - Thoroughly wash exposed area for at least 15 minutes. Remove contaminated clothing. Launder contaminated clothing before reuse. Get medical attention if irritation persists.
Ingestion - If swallowed, if conscious, give plenty of water. Immediately call a physician.
Inhalation - Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm, quiet, and get medical attention.

5. FIREFIGHTING PROCEDURES

Extinguisher Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide..
Special Fire fighting Procedures: Firefighters should wear full protective equipment and NIOSH approved self-contained breathing apparatus.
Unusual Fire and Explosion Hazards: Heated to decomposition, however, toxic oxides of sulfur may be evolved.

6. SPILL OR LEAK PROCEDURES

Steps to be Taken in Case Material is Released or Spilled: Ventilate area of spill of Sodium Picosulfate. Clean-up personnel should wear proper protective equipment. Avoid creating dust. Sweep or scoop up and containerize for disposal. Prevent entry into sewers, basements or confined areas.

7. SPECIAL PRECAUTIONS

Precautions to be Taken in Handling or Storing: Store Sodium Picosulfate tightly closed in a cool, dry, well ventilated area suitable for general chemical storage. Provide appropriate exhaust ventilation at places where dust is formed. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.

8. SPECIAL PROTECTION INFORMATION

Exposure limits: No data available
Respiratory Protection (Specify Type): None needed under normal conditions of use with adequate ventilation. NIOSH approved equipment should be worn if PELs are exceeded.
Ventilation:
Local Exhaust: Yes
Mechanical (General): Yes
Protective Gloves: Rubber, neoprene, PVC, or equivalent.
Eye Protection: Splash proof chemical safety goggles should be worn at all times.
Other Protective Clothing or Equipment: Lab apron, eye wash, and safety shower.

9. PHYSICAL DATA

Physical State: White crystalline solid
Molecular Formula: C18H13NNa2O8S2
Molecular Weight: 499.42
Melting Point:
272-275C
Boiling Point: N/A
Vapor Pressure: N/A
Specific Gravity (H2O=1): N/A
Solubility in Water: Soluble
Appearance and Odor: Sodium Picosulfate is white crystals or powder, no odor.

10. REACTIVITY DATA

Stability: Sodium Picosulfate is stable
Conditions to Avoid: Dust generation, Incompatiblities
Incompatibility (Materials to Avoid): Strong Oxidizing Agents.
Hazardous Decomposition Products: Nitrogen oxides, Sulfur oxides, Carbon oxides, Sodium oxides.
Hazardous Polymerization: Will not occur

11. TOXICITY DATA

Toxicity Data: LD50 Oral - Mouse - 5989 mg/kg
Investigated as a tumorigen, mutagen, reproductive effector. No LD50/LC50 information found relating to normal routes of occupational exposure.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.

12. ECOLOGICAL DATA

Toxicity to fish: No data available.
Toxicity to daphnia and other aquatic invertebrates: No data available.
Environmental Toxicity: This material is not expected to be toxic to aquatic life.

13. DISPOSAL INFORMATION

Waste Disposal Methods: Dispose in accordance with all applicable regulations.

14. TRANSPORT INFORMATION

DOT (US): Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
ADT/RID: Not dangerous goods

15. REGULATORY INFORMATION

USA Regulations:
OSHA: None of the chemicals in this product are considered highly hazardous by OSHA.
EINECS EC Number: 233-120-9

16. ADDITIONAL INFORMATION

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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