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Sodium Salicylate BP Grade n Pure Manufacturers, SDS GHS MSDS Sheet
Sodium Salicylate: CAS Number: 54-21-7, EINECS EC Number: 200-198-0, Molecular Formula: HOC6H4COONa, Molecular Weight: 160.11, HS Code ---**
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SDS MSDS Sheet of Sodium Salicylate Manufacturers
Pure BP Grade
Sodium Salicylate is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug.
Sodium Salicylate BP Grade
C7H5NaO3 -- 160.1 -- 54-21-7
Action and use: Anti-inflammatory; analgesic.
Content: 99.0 per cent to 101.0 per cent (dried substance).
Appearance: White or almost white, crystalline powder or small, colourless crystals or shiny flakes.
Solubility: Freely soluble in water, sparingly soluble in ethanol (96 per cent).
First identificationıA, C.
Second identificationıB, C.
A. Infrared absorption spectrophotometry.
B. Solution S (see Tests) gives the reactions of salicylates.
C. It gives reaction (b) of sodium.
Solution S: Dissolve 5.0 g in carbon dioxide-free water prepared from distilled water and dilute to 50 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution BY6.
Acidity: To 20 ml of solution S add 0.1 ml of phenol red solution. The solution is yellow. Not more than 2.0 ml of 0.01 M sodium hydroxide is required to change the colour of the indicator to violet-red.
Chlorides: Maximum 200 ppm.
Sulphates: Maximum 600 ppm.
Heavy metals: Maximum 20 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.00 g by drying in an oven at 105C.
Dissolve 0.130 g in 30 ml of anhydrous acetic acid. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically.
1 ml of 0.1 M perchloric acid is equivalent to 16.01 mg of C7H5NaO3.
For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
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Last : 23 March, 2017
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Sodium Salicylate SDS MSDS Sheet, Material Safety Data Sheet
1. Product Identification
Synonyms: 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt
CAS No.: 54-21-7
EINECS EC Number: 200-198-0
Molecular Weight: 160.1
Chemical Formula: HOC6H4COONa
Suppliers: As per letterhead
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Labeling according GHS & Regulation (EC) No 1272/2008
GHS Label Elements
Signal Words: Warning
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
P264: Wash … thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.
P501: Dispose of contents/container to authorized agents only.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Xn Harmful R22
Xi Irritant R36/38
For the full text of the H-statements & R-phrases mentioned in this Section, see Section 16.
3. Composition/Information on Ingredients
Ingredient: Sodium Salicylate
CAS No.: 54-21-7
EINECS EC Number: 200-198-0
Percent: 97 - 100%
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Flammability of the Product: May be combustible at high temperature.
Auto-Ignition Temperature: Not applicable.
Products of Combustion: Fumes, Metallic Oxide Carbon dioxide & Carbon Monoxide.
Fire: Sodium Salicylate is slightly flammable on heating.
Explosion: Slightly explosive on heating.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures or when moistened under fire conditions, it may produce toxic or irritating fumes. On decomposition it may emit carbon monoxide. Containers may explode on heating
6. Accidental Release Measures
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid touching the spilled material. Do not let the product enter drains. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
7. Handling and Storage
Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment.
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Wash hands thoroughly after handling. Provide appropriate exhaust ventilation at places where dust is formed. If you feel unwell, seek medical attention.
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Keep away from heat, sun light and oxidizing agents.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not Specified.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: Sodium Salicylate is colorless white powder flakes or crystals.
Odor: It is odorless.
Solubility: It is soluble in water.
Specific Gravity: about 2.50
Molecular Weight: 160.1
Molecular formula: HOC6H4COONa
% Volatiles by volume @ 21C (70F): -
Boiling Point: NA
Melting Point: NA
Vapor Density (Air=1): No information found.
Vapor Pressure (mm Hg): No information found.
Evaporation Rate (BuAc=1): No information found.
10. Stability and Reactivity
Stability: Sodium Salicylate is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits carbon monoxide & fumes when heated to decomposition. It may form metallic oxide harmful gases.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, acids, strong bases, ferric salts, lead acetate, lead, lime water, silver nitrate, iodine.
Conditions to Avoid: Incompatible materials, light, dust generation, excess heat, exposure to moist air or water.
11. Toxicological Information
Harmful if swallowed. Harmful if inhaled. Irritating to skin.
ORL-RAT LD50 930 mg kg-1
ORL-Mouse LD50 540 mg kg-1
Carcinogenic Effects: Not a reported carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: Mutagenic effects have occurred in experimental animals.
Teratogenic Effects: Teratogenic effects have occurred in experimental animals.
Developmental Toxicity: Adverse reproductive effects have occurred in experimental animals.
12. Ecological Information
Toxicity to fish: LC50 - Pimephales promelas (fathead minnow) - 1.370 mg/l - 96 h
Environmental Fate: This substance is expected to have a high biological oxygen demand. It is readily biodegradable and has low bioconcentration potential.
Environmental Toxicity: NA
BOD5 and COD: Not available. This substance is expected to have a high biological oxygen demand.
Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
14. Transport Information
US DOT & ADR/RID: Not regulated.
Canada TDG Classification: Not regulated.
IATA: Not regulated.
15. Regulatory Information
OSHA Hazards: Not classed as Highly Hazardous as per OSHA
SARA 302 Components: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA Codes: CAS # 54-21-7: immediate, delayed.
SARA 313 Components: No chemicals in this material are subject to the reporting requirements
Massachusetts Right To Know Components: Not Listed
Pennsylvania Right To Know Components: Not Listed
New Jersey Right To Know Components: Not Listed
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
Health & Safety Reporting List: None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules: None of the chemicals in this product are under a Chemical Test Rule.
Section 12b: None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule: None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs: Not Listed
HMIS (Perceived): Health Hazard: 2, Fire Hazard: 1, Reactivity: 0, Personal Protection: E
NFPA (Perceived): Health: 2, Flammability: 1, Reactivity: 0
WGK (Water Danger/Protection): CAS# 54-21-7: 1
Canada - DSL/NDSL: CAS# 54-21-7 is listed on Canada's DSL List.
Canada - WHMIS: This product has a WHMIS classification of D2B.
16. Other Information
EINECS: EC Number: 200-198-0
H302 = Harmful if swallowed.
H315 = Causes skin irritation.
H319 = Causes serious eye irritation.
Xi = Irritant.
R22 Harmful if swallowed.
R36/38 Irritating to eyes and skin.
S-2 Keep out of reach of children.
S-24/25 Avoid contact with skin and eyes.
S-26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S-46 If swallowed seek medical advice immediately and show this container label.
DISCLAIMER: The information and recommendations set forth herein (hereinafter "Information") are presented in good faith and believed correct as of the date hereof. It is compiled from various sources and it is not necessarily all inclusive nor fully adequate in every circumstance. In addition, these suggestions should not be confused with nor followed in violation of applicable laws, regulations, rules or insurance requirements applicable. This MSDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.