Chloramphenicol USP BP Ph Eur Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Chloramphenicol, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Chloramphenicol CAS Number 56-75-7, EINECS EC Number: 200-287-4, Molecular Formula: C11H12Cl2N2O5, Molecular Weight: 323.13, HS Code 29414000

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SDS MSDS Sheet of Chloramphenicol Manufacturers

Chloramphenicol
USP BP Ph Eur Grade Suppliers
Chloramphenicol

Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa.

General Properties and Specifications of Chloramphenicol:
Appearance: White to pale yellow crystalline powder.
Solubility of 10% solution in Ethanol: Clear
Assay: 98 - 102%
Melting Point: 149C to 153C literature.
Specific rotation: +18.5° to +20° (C=6, Ethanol)
Sulfated Ash: 0.1% maximum.
Loss on drying: 0.5% maximum.
Chloride (CI): 0.01% maximum.
Acidity: 2 ml N% maximum.
Suitability for Tissue Culture: Passes.
Storage : 0C to 4C. OK to Freeze. Short term shipping may be ambient.


Chloramphenicol USP Grade Specifications:
C11H12Cl2N2O5 CAS 323.13
Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-.
d-threo-(−)-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]acetamide CAS 56-75-7
UNII: 66974FR9Q1

Identification:
A: Infrared Absorption.
B: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Melting range: between 149C and 153C.
Specific rotation: between +17.0° and +20.0°.
Crystallinity: meets the requirements.
Bacterial Endotoxins Test: Where Chloramphenicol is intended for use in preparing injectable dosage forms, it contains not more than 0.2 USP Endotoxin Unit per mg of chloramphenicol.
Sterility Tests: Where the label states that Chloramphenicol is sterile, it meets the requirements when tested as directed for Membrane Filtration under Test for Sterility of the Product to be Examined, except to use 1 g of solid specimen.
pH: between 4.5 and 7.5, in an aqueous suspension containing 25 mg per mL.
Chromatographic purity: To pass the test.


Chloramphenicol BP Ph Eur Grade:
C11H12Cl2N2O5 --- 323.1 CAS 56-75-7
Action and use: Antibacterial.

DEFINITION
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide.
Content: 97.5 per cent to 102.0 per cent (dried substance).

CHARACTERS
Appearance: White, greyish-white or yellowish-white, fine, crystalline powder or fine crystals, needles or elongated plates.
Solubility: Slightly soluble in water, freely soluble in ethanol (96 per cent) and in propylene glycol.
A solution in anhydrous ethanol is dextrorotatory and a solution in ethyl acetate is laevorotatory.

IDENTIFICATION
First identification: A
Second identification: B
A. Infrared absorption spectrophotometry.
B. Melting point.
Results 149C to 153C.

TESTS
Acidity or alkalinity: To 0.1 g add 20 mL of carbon dioxide-free water, shake and add 0.1 mL of bromothymol blue solution. Not more than 0.1 mL of 0.02 M hydrochloric acid or 0.02 M sodium hydroxide is required to change the colour of the indicator.
Specific optical rotation: + 18.5 to + 20.5.
Related substances: To pass the test.
Chlorides: Maximum 100 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 2.0 g.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

alpha-Chloralose or α-Chloralose

Chloramphenicol

Phenol

Phenyramidol Hydrochloride

Phenoxyethanol

4-(4-Chlorophenyl)-4-Hydroxypiperidine

Chlorhexidine Base

3-(4-Chlorophenyl)glutaric Anhydride.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

Manufacturers india
Copyright and Usual Disclaimer is Applicable.
Last 22 December, 2023

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Chloramphenicol SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
28-Oct-2

Section 1: Product and Company Identification

Product Name & Other Names: Chloramphenicol.
CAS No.: 56-75-7
EINECS, EC Number: 200-287-4
Molecular Weight: 323.13
Chemical Formula: C11H12Cl2N2O5
Relevant uses and uses advised against (if any): Laboratory chemicals. Industrial use.
Supplier: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Serious eye damage (Category 1), H318
Carcinogenicity (Category 2), H351
Reproductive toxicity (Category 2), H361

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Health Hazard
Health Hazard

GHS Label Elements
Corrosive
Corrosive

Signal Words: Danger

Hazard statements:
H318 Causes serious eye damage.
H351 Suspected of causing cancer.
H361: Suspected of damaging fertility. Suspected of damaging the unborn child.

Precautionary statements:
P202: Do not handle until all safety precautions have been read and understood.
P210: Keep away from heat/sparks/open flames/hot surfaces – No smoking.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P337+313: If eye irritation persists get medical advice/attention.
P333+313: If skin irritation or a rash occurs: Get medical advice/attention.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:

Hazard Symbols:
Xn Harmful
C Corrosive
Risk Phrases:
R41 Risk of serious damage to eyes.
R45 May cause cancer.
R63 Possible risk of harm to the unborn child.

Section 3: Composition / Information on Ingredients

Product Name & Other Names: Chloramphenicol.
CAS No.: 56-75-7
EINECS, EC Number: 200-287-4

Section 4: First Aid Measures

Always seek medical attention after first aid measures are provided.

Eyes: Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally.
Skin: Immediately flush skin with excess water for 15 minutes while removing contaminated clothing.
Ingestion: Call Emergency Medical immediately. Rinse mouth with cold water. Give victim 1-2 cups of water or milk to drink. Induce vomiting immediately.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration.

Section 5: Fire Fighting Measures

It is non-flammable solid, however, it can burn at high temperatures. When heated to decomposition, emits fumes.
Protective equipment and precautions for firefighters:
Use dry sand, foam, or dry chemical to extinguish fire. Firefighters should wear full fire-fighting turn-out gear and respiratory protection. Cool container with water spray.
Special hazards arising from the substance: Carbon oxides, nitrogen oxides, chlorine compounds, and toxic fumes.
Suitable fire-fighting medium: Use dry sand, dry chemical, or alcohol-resistant foam. Use water spray to cool unopened containers.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Section 6: Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Section 7: Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, heat combustible substances. Storage: 0C to 4C. OK to Freeze. Short term shipping may be ambient.

Section 8: Exposure Controls / Personal Protection

Exposure guidelines: This product does not contain any hazardous materials with occupational exposure limits established by the region-specific regulatory bodies.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Section 9: Physical and Chemical Properties

Physical state and appearance: White to pale yellow crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: Not available.
Relative density: Not available.
Melting Point: 149C to 153C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Low solubility in water.
Viscosity: Not available.
Molecular Weight: 323.13
Chemical Formula: C11H12Cl2N2O5

Section 10: Stability and Reactivity

Avoid heat and ignition sources.
Stability: Stable under normal conditions of use and storage.
Incompatibility: Moisture, heat, combustible substances, oxidizing agents, acids.
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, chlorine compounds, and toxic fumes.
Hazardous Polymerization: Has not been reported.

Section 11: Toxicology Information

LD50 Oral, Rat: 2500 mg/kg.
LC50 Inhalation Rat: 1.07 mg/l; 4 h ; dust/mist.
LDLO Dermal Rabbit: 10,000 mg/kg
May affect genetic material (mutagenic).
Carcinogenicity: May cause cancer.
Reproductive Effects: Suspected of damaging the unborn child. Suspected of damaging fertility.
Developmental Effects: No information available.
Teratogenicity: No information available.

Section 12: Ecological Information

Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - 345 mg/l - 48 h.
Persistence and degradability: Unlikely to persist due to water solubility.
Bioaccumulation/ Accumulation: No information available.
Mobility in soil: Likely to be mobile due to water solubility.

Section 13: Disposal Considerations

Check with all applicable local, regional, and national laws and regulations.

Section 14: Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IMDG/IMO & IATA: Not regulated.

Section 15: Regulatory Information

USA:
SARA 311/312 Hazard Categories
: Acute Health Hazard, Chronic Health Hazard. See section 2.

Section 16: Other Information

European Labeling in Accordance with EC Directives:
H318 Causes serious eye damage.
H351 Suspected of causing cancer.
H361: Suspected of damaging fertility. Suspected of damaging the unborn child.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xn Harmful
C Corrosive
Risk Phrases:
R41 Risk of serious damage to eyes.
R45 May cause cancer.
R63 Possible risk of harm to the unborn child.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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