Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid USP BP Ph Eur Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid CAS Number 54-31-9, EINECS EC Number: 200-203-6, Molecular Formula: C12H11ClN2O5S, Molecular Weight: 330.74, HS Code 29241900

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SDS MSDS Sheet of Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid Manufacturers

Furosemide
Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid USP BP Ph Eur Grade Suppliers
Furosemide or Frusemide

Furosemide or Frusemide is an odorless white to slightly yellow crystalline powder. It is used as a diuretic drug. It is almost tasteless.

General Properties and Specifications of Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid:
Appearance: Off - white powder.
Odor: Odorless
Solubility of 1% solution in acetone: Clear.
Assay: 98.5% minimum.
Melting Point: 210C to 220C literature.
Boiling Point: 582C predicted.
Loss on drying: 0.5% maximum.
Solubility: Very slightly soluble in water.
Storage: Room temperature. Preferably refrigerate.


Furosemide USP Grade Specifications:
C12H11ClN2O5S -- 330.74
Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-;
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid CAS 54-31-9
UNII: 7LXU5N7ZO5

DEFINITION
Furosemide contains NLT 98.0% and NMT 102.0 of furosemide (C12H11ClN2O5S), calculated on the dried basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
C. The UV spectrum of the major peak of the Sample solution corresponds to that of the Standard solution, as obtained in the Assay.
Residue on Ignition: NMT 0.1%
Organic Impurities: To pass the test by Chromatography.
Loss on Drying: NMT 1.0% at 105C for 3 h.


Furosemide BP Ph Eur Grade Specifications:
C12H11ClN2O5S --- 330.7 CAS54-31-9
Action and use: Loop diuretic.

DEFINITION
4-Chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid.
Content: 98.5 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.

IDENTIFICATION
First identification: B
Second identification: A, C
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Dissolve about 25 mg in 10 mL of ethanol (96 per cent). Mix 5 mL of the solution and 10 mL of water. To 0.2 mL of this solution add 10 mL of dilute hydrochloric acid and heat under a reflux condenser for 15 min. Allow to cool and add 18 mL of 1 M sodium hydroxide and 1 mL of a 5& g/L solution of sodium nitrite. Allow to stand for 3 min, add 2 mL of a 25 g/L solution of sulfamic acid and mix. Add 1 mL of a 5 g/L solution of naphthyl ethylenediamine dihydrochloride. A violet-red colour develops.

Appearance of solution: The solution is clear and not more intensely coloured than reference solution.
Related substances: To pass the test by chromatograph.
Chlorides: Maximum 200 ppm.
Sulfates: Maximum 300 ppm.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

Anthranilamide

N-Chlorosuccinimide

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide

N-Hydroxysuccinimide

Nicotinamide or Niacinamide

Succinimide or Butanimide

Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Copyright and Usual Disclaimer is Applicable.
Last 26 October, 2023

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Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid SDS GHS Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
26-10-32

1. Product Identification

Product Name & Other Names: Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid.
CAS Number: 54-31-9
EINECS EC Number
: 200-203-6
Molecular Formula
: C12H11ClN2O5S
Molecular Weight
: 330.74
Relevant uses and uses advised against (if any): Fracturing and Industrial Manufacturing Use.
Supplier: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, Oral (Category 4), H302
Reproductive toxicity Category 1B - H360
Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Health Hazzard
Health Hazard

GHS Label Elements
Irritant
Irritant

Signal Words: Danger

Hazard Statements:
H302 Harmful if swallowed.
H360: May damage the unborn child. May damage fertility.

Precautionary Statements:
P201: Obtain special instructions before use.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash contaminated parts thoroughly after handling.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P281: Use personal protective equipment as required.
P362: Take off contaminated clothing and wash before reuse.
P301+330+331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes.
P308 + P310: IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/national regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Hazard Symbol:
Xn = Harmful.
Risk Phrases:
R22 Harmful if swallowed
R61 May cause harm to the unborn child.

3. Composition/Information on Ingredients

Product Name & Other Names: Furosemide or Frusemide or 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid.
CAS Number: 54-31-9
EINECS EC Number
: 200-203-6

4. First Aid Measures

Always seek medical attention after first aid measures are provided.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing and shoes before reuse.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush your eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.

5. Fire Fighting Measures

Fire: Combustible at high temperature. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapors is possible in the event of fire. In a fire or if heated, a pressure increase will occur and the container may burst.
Suitable extinguishing media: Water spray, dry powder, foam, carbon dioxide. Avoid solid water stream.
Products of Combustion: Oxides of carbon and sulfur, chlorine compounds, along with toxic fumes will be formed.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide. Use means suitable for extinguishing surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the positive pressure mode.

6. Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental  precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: For small spills use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to legal requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and disposing of it according to legal requirements.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Product should be worked up in closed equipment as far as possible. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing agents. Containers of this material may be hazardous when empty. Storage: Room temperature.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: Contains no substances with occupational exposure limit values. Ensure minimum contact.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded and engineering controls are not feasible, a full face piece particulate respirator (NIOSH type N100 filters) may be worn for up to 50 times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. If oil particles (e.g., lubricants, cutting fluids. glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance: Off - white powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: Not available.
Relative density: Not available.
Melting point/freezing point: 210C to 220C literature.
Initial boiling point and boiling range: 582C predicted.
Flash Point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Very slightly soluble in Water.
Viscosity: Not available.
Molecular Formula: C12H11ClN2O5S
Molecular Weight
: 330.74

10. Stability and Reactivity

Stability: It is stable under ordinary conditions of use and storage. Forms explosive mixtures with air on intense heating. Dust explosion for fine distribution, when whirled up in air.
Hazardous Decomposition Products: Toxic gases and vapors may be released if involved in a fire. Oxides of carbon and sulfur, chlorine compounds, along with toxic fumes will be formed.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents.
Conditions to Avoid: Incompatibles, heat, sunlight.

11. Toxicological Information

LD50 Oral Rabbit: > 800 mg/kg.
Carcinogenic Effects: Not a reported carcinogen.
Reproductive Toxicity: May damage the unborn child. May damage fertility.
Developmental Toxicity: Not available.

12. Ecological Information

Toxicity to fish: No data available.
Persistence and Degradability: No data available.
Mobility: No data available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused material in accordance with law.

14. Transport Information

USA DOT & ADR/RID: Not regulated.
IATA & IMDG: Not regulated.

15. Regulatory Information

USA:
SARA 311/312: Acute, Chronic. See section 2.
California Proposition 65: Not listed.

16. Other Information

Hazard Statements:
H302 Harmful if swallowed.
H360: May damage the unborn child. May damage fertility.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn = Harmful.
Risk Phrases:
R22 Harmful if swallowed
R61 May cause harm to the unborn child.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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