Imatinib Mesylate Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Imatinib Mesylate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Imatinib Mesylate: CAS Number: 220127-57-1, EINECS EC Number: 606-892-3, Molecular Formula: C30H35N7O4S or C29H31N7O-CH4SO3, Molecular Weight: 589.7, HS Code ---**

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For SDS MSDS Sheet Click
SDS MSDS Sheet of Imatinib Mesylate Manufacturers

Imatinib Mesylate
Pure Suppliers
Imatinib Mesylate

Imatinib mesylate is a white to off-white crystalline powder. Its molecular formula is C29H31N7O-CH4SO3. Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Soluble in aqueous buffers =<pH 5.5, but very slightly soluble in neutral to alkaline aqueous buffers; freely soluble to very soluble in dimethyl sulfoxide, methanol, and ethanol; insoluble in n-octanol, acetone, and acetonitrile.
Chemical Name: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate

Specifications of Imatinib Mesylate:
CAS Number: 220127-57-1
Molecular Formula: C30H35N7O4S or C29H31N7O-CH4SO3
Molecular Weight: 589.70
Description: White to yellowish white powder.
Identification: By IR.
Solubility: Freely soluble in water and sparingly soluble in methanol.
Melting Range: 209C to 225C.
Moisture Content by KF: Not more than 0.5%.
Heavy Metals: Not more than 20 ppm In-house
Related substances by HPLC
a) Individual Impurity Not more than 0.5%
b) Total Impurities Not more than 1.0%
Assay by HPLC (on anhydrous basis): 99.0 to 101.0%.
Storage: Well-closed container, protected from direct sunlight and moisture.

Imatinib Mesilate BP Ph Eur Grade:
Ph Eur
C30H35N7SO4 --- 589.7 --- CAS 220127-57-1 
Action and use: Cytotoxic.

4-[(4-Methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide methanesulfonate.
Content: 98.0 per cent to 102.0 per cent (anhydrous substance).

It is considered that alkyl methanesulfonate esters are genotoxic and are potential impurities in imatinib mesilate. The manufacturing process should be developed taking into consideration the principles of quality risk management, together with considerations of the quality of starting materials, process capability and validation. The general methods 2.5.37. Methyl, ethyl and isopropyl methanesulfonate in methanesulfonic acid, 2.5.38. Methyl, ethyl and isopropyl methanesulfonate in active substances and 2.5.39. Methanesulfonyl chloride in methanesulfonic acid are available to assist manufacturers.

Appearance: White or almost white, slightly brownish or yellowish powder; yellow or pale yellow, very hygroscopic, for the amorphous form.
Solubility: Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It shows polymorphism.

Infrared absorption spectrophotometry: To pass the test.

Impurity profile: To pass the test.
Related substances: To pass the test.
Water: Maximum 3.0 per cent, determined on 1.00 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.


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Last 3 October, 2023

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Imatinib Mesylate SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet

1. Product Identification

Product Name/Synonyms: Imatinib Mesylate or 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate.
CAS No.: 220127-57-1
EINECS EC Number: 606-892-3
Molecular Weight: 589.7
Chemical Formula: C30H35N7O4S or C29H31N7O-CH4SO3
Recommended usage: Industrial Manufacturing.
Suppliers: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, oral Category 4

Labeling according Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: Warning

Hazard statements:
H302: Harmful if swallowed.

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+ P352 - IF ON SKIN: Wash with plenty of soap and water.
P305+ P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.

Labeling in accordance with Directive 67/548/EEC:
Xn Harmful
R22: Harmful if swallowed.

3. Composition/Information on Ingredients

Product Name/Synonyms: Imatinib Mesylate or 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate.
CAS No.: 220127-57-1
EINECS EC Number: 606-892-3

4. First Aid Measures

Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
Notes to Physician: Treat symptomatically

5. Fire Fighting Measures

Fire: It is not considered to be a fire hazard. However it will burn at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Use water spray to cool fire-exposed containers.
Special hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides, Fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece.

6. Accidental Release Measures

Use personal protective equipment. Avoid dust formation. Avoid breathing dust, vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Do not let product enter drains.
Ventilate area of leak or spill. Wear appropriate personal protective equipment. Pick up spills and place in a suitable container for reclamation or disposal, using a method that does not generate dust.

7. Handling and Storage

Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid ingestion and inhalation. Keep in a tightly closed container, stored in a cold, dry, ventilated area. Protect against physical damage. Avoid dust formation and control ignition sources. Isolate from incompatible substances. Containers of may be hazardous when empty.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: None established.
Ventilation System: In general, dilution ventilation is a satisfactory health hazard control for this substance. However, if conditions of use create discomfort to the worker, a local exhaust system should be considered.
Personal Respirators (NIOSH Approved): Not expected to require personal respirator usage. For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.

9. Physical and Chemical Properties

Appearance: White to yellowish white powder.
Odor: Odorless.
Solubility: Freely soluble in water and sparingly soluble in methanol.
pH: No information found.
Boiling Point: Decomposes.
Melting Point: 209C to 225C literature.
Flash Point: No data available.
Auto-ignition temperature: No data available.
Molecular Weight: 589.7
Chemical Formula: C30H35N7O4S or C29H31N7O-CH4SO3.

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: May produce oxides of nitrogen, sulfur and carbon along with fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting and incompatibles.

11. Toxicological Information

Toxicity Data:
Oral TDLO (human): 79.8 mg/kg/1W (intermittent)
Oral TDLO (man): 60.2 mg/kg/1W
Oral TDLO (rat): 450 mg/kg/3D (intermittent)
Oral TDLO (mouse): 600 mg/kg/6D (intermittent)
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

12. Ecological Information

Environmental Fate: Not available.
Persistence and degradability: No data available
Toxicity: No data available
Bioaccumulative potential: No data available
Mobility in soil: No data available
PBT and vPvB assessment: no data available

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. Dispose of container and unused material in accordance with legal requirements.

14. Transport Information

DOT: Not regulated
TDG: Not regulated
IATA: Not regulated
IMDG/IMO: Not regulated
ADR/RID: Not regulated

15. Regulatory Information

SARA 302
: Not applicable.
SARA 313: Not applicable.
SARA 311/312 Hazardous Categorization: Acute Health Hazard.
California Proposition 65: This product does not contain any Proposition 65 chemicals

16. Other Information

Xn Harmful
R22: Harmful if swallowed.

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.