Nicorandil BP Ph Eur IP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Nicorandil BP Ph Eur IP Grade, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy Portugal, Bangladesh, etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Nicorandil CAS Number 65141-46-0, EINECS EC Number: 265-514-1, Molecular Formula: C8H9N3O4, Molecular Weight: 211.17, HS Code 29333919 or 29420090
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SDS MSDS Sheet of Nicorandil Manufacturers
Nicorandil
BP Ph Eur IP Grade Suppliers
Nicorandil (CAS 65141-46-0) is a nicotinamide derivative used to treat chronic stable angina pectoris by acting as a potassium channel opener and nitric oxide donor. It relaxes vascular smooth muscle, increases oxygen supply to the heart, and is typically prescribed when other treatments are unsuitable.
General Properties and Specifications of Nicorandil:
Appearance: White to Almost white powder or crystals. Moisture Sensitive
Assay: 99% minimum.
Melting Point: 92C to 93C literature.
Solubility: Slightly soluble in water. Freely soluble in methanol, ethanol, acetone, and glacial acetic acid.
Storage: Freezer. -20C.
Nicorandil BP Ph Eur Grade:
C8H9N3O4 -- 211.2 CAS 65141-46-0
Action and use: Potassium channel opener
Preparation: Nicorandil Tablets.
DEFINITION
2-[(Pyridin-3-ylcarbonyl)amino]ethyl nitrate.
Content: 99.0 per cent to 101.0 per cent (anhydrous substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Sparingly soluble in water, freely soluble in anhydrous ethanol, practically insoluble in heptane.
IDENTIFICATION
Infrared absorption spectrophotometry.
TESTS
pH: 5.5 to 7.0.
Dissolve 0.25 g in carbon dioxide-free water and dilute to 25& mL with the same solvent.
Related substances: To pass the test by Liquid chromatography.
Sulfates: Maximum 100 ppm.
Water: Maximum 0.5 per cent.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
Storage: At a temperature of 2C to 8C.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
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Manufacturers:
MUBY CHEMICALS
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Last 3 May, 2026
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Nicorandil SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 03-May-26
1. Product Identification
Product Name & Other Names: Nicorandil
CAS No.: 65141-46-0
EINECS EC Number: 265-514-1
Molecular Formula: C8H9N3O4
Molecular Weight: 211.17
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.
2.Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008:
Acute toxicity, Oral Category 4, H302
Serious eye damage/eye irritation Category 1, H318
Labeling according to GHS & Regulation (EC) No 1272/2008
GHS Label Elements Corrosive |
Signal Words: Danger
Hazard statements:
H302: Harmful if swallowed.
H318: Causes serious eye damage.
Precautionary statements:
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P314: Get Medical advice/attention if you feel unwell.
P362: Take off contaminated clothing and wash before reuse.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with soap and water.
P332+313: If skin irritation occurs: Get medical advice/attention.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P330: Rinse mouth.
P501 Dispose of contents/ container to an approved waste disposal plant.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn: Harmful
C: Corrosive,
Risk Phrase:
R22: Harmful if swallowed.
R41 Risk of serious damage to eyes.
3. Composition/Information on Ingredients
Product Name & Other Names: Nicorandil
CAS No.: 65141-46-0
EINECS EC Number: 265-514-1
4. First Aid Measures
Always seek medical attention after first aid measures are provided.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Do not induce vomiting unless as directed by medical personnel. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reusing. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard, however, heating may lead to fire. At fire temperatures it begins to corrode metals and may dissociate into ammonia, oxides of nitrogen and carbon dioxide.
Explosion: Not available.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Water spray may be used to keep fire exposed containers cool.
Special Information In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Avoid breathing dust. Use a shovel to put the material into a convenient waste disposal container. Do not let products enter drains. Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed. containers for disposal.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling it. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original containers. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like concentrated acids, strong bases, oxidizing agents. Store away from sources of heat, moisture. Storage: Freezer. -20C.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: Not established
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): If the exposure limit is exceeded and engineering controls are not feasible, a half face piece particulate respirator (NIOSH type N95 or better filters) may be worn for up to ten times the exposure limit or the maximum use concentration specified by the appropriate regulatory agency or respirator supplier, whichever is lowest. A full-face piece particulate respirator (NIOSH type N100 filters) may be worn up to 50 times the exposure limit, or the maximum use concentration specified by the appropriate regulatory agency, or respirator supplier, whichever is lowest. If oil particles (e.g. lubricants, cutting fluids, glycerin, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to Almost white powder or crystals. Moisture Sensitive
Odor: Not available.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 92C to 93C literature.
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor Pressure (mm Hg): Not available.
Vapor Density (Air=1): Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water. Freely soluble in methanol, ethanol, acetone, and glacial acetic acid.
Viscosity: Not available.
Molecular Formula: C8H9N3O4
Molecular Weight: 211.17
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Involvement in a fire causes decomposition to form carbon dioxide and ammonia.
Hazardous Polymerization: Will not occur.
Incompatibilities: Concentrated acids, strong bases, oxidizing agents, heat.
11. Toxicological Information
Acute toxicity:
LD50 Oral - Rat - male and female: 1220 mg/kg
Carcinogenicity: The product is not classed as carcinogen by IARC, ACGIH, NTP, OSHA.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.
12. Ecological Information
Toxicity to fish: LC50 Pimephales promelas (fathead minnow): No information available.
Persistence and Degradability: No information available.
Mobility: Mobile due to water solubility.
Bioaccumulation/ Accumulation: Not likely to accumulate.
Results of PBT and vPvB assessment: This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
13. Disposal Considerations
Whatever cannot be saved for recovery, or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused material in accordance with legal requirements.
14. Transport Information
DOT USA ADR/RID Europe: Not Regulated
IMDG: Not dangerous goods
IATA: Not dangerous goods.
15. Regulatory Information
USA:
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards: Acute Health Hazard
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
16. Other Information
European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H318: Causes serious eye damage.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn: Harmful
C: Corrosive,
Risk Phrase:
R22 Harmful if swallowed.
R41 Risk of serious damage to eyes.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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