Riboflavin or Vitamin B2 USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Riboflavin or Vitamin B2, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Riboflavin or Vitamin B2 CAS Number 83-88-5, EINECS EC Number: 201-507-1, Molecular Formula: C17H20N4O6, Molecular Weight: 376.36, HS Code 29362310 or 29362300

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Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Riboflavin or Vitamin B2.

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SDS MSDS Sheet of Riboflavin or Vitamin B2 Manufacturers

Vitamin B2 USP BP Ph Eur FCC Food Grade Suppliers

Riboflavin, also known as vitamin B2, is a vitamin found in food and sold as a dietary supplement. Riboflavin or Vitamin B2 is one of the B vitamins, which are all water soluble. Riboflavin is naturally present in some foods, added to some food products, and available as a dietary supplement. In foods it has an E number of E101, E101(iii)

General Properties and Specifications of Riboflavin or Vitamin B2:
Appearance: Orange yellow crystalline powder.
Solubility of 2% solution in 0.5N NaOH: Clear orange.
Assay: 98% minimum.
Loss on drying: 1.5% maximum.
Sulfated Ash: 0.1% maximum.
pH: 5.5 - 7.2 for 0.07 g/l in water @ 20C.
Relative Density: 1.65 (Predicted).
Melting Point: 280C to 290C literature.
Boiling Point: 710C (Predicted).
Solubility: Very slightly soluble in water.
Suitability for Cell Culture: Passes.
Bacterial Endotoxin Test (BET) (EU/mg = IU/mg): <0.05 EU/mg.
Storage: Room temperature. Preferably refrigerate. In a light resistance container.

Riboflavin USP Grade Specifications:
C17H20N4O6 376.36
Riboflavine CAS 83-88-5

Riboflavin contains NLT 98.0% and NMT 102.0% of riboflavin (C17H20N4O6), calculated on the dried basis.

A. Color and Fluorescence of Solution:
Sample solution: 0.01 mg/mL in water
Analysis: Alternately expose to transmitted light and long-wavelength UV light.
Acceptance criteria: The Sample solution is pale greenish yellow by transmitted light. By reflected light, it exhibits an intense yellowish-green fluorescence that disappears upon the addition of mineral acids or alkalies.

Residue on Ignition: NMT 0.3%
Limit of Lumiflavin: To pass the test.
Optical Rotation, Specific Rotation:
Sample solution: 5 mg/mL in 0.05 M carbonate-free sodium hydroxide.
Analysis: Measure the specific rotation within 30 min of preparation.
Acceptance criteria: −115° to −135°
Loss on Drying: Dry 500 mg at 105C for 2 h. It loses NMT 1.5% of its weight.

Riboflavin BP Ph Eur Grade Specifications:
C17H20N4O6 --- 376.4 CAS 83-88-5
Action and use: Vitamin B2.

This monograph applies to riboflavin produced by fermentation.
Content: 97.0 per cent to 103.0 per cent (dried substance).

Appearance: Yellow or orange-yellow, crystalline powder.
Solubility: Very slightly soluble in water, practically insoluble in ethanol (96 per cent).
Solutions deteriorate on exposure to light, especially in the presence of alkali.It shows polymorphism.

A. Specific optical rotation.
B. Thin-layer chromatography.
C. Dissolve about 1 mg in 100 mL of water. The solution has, by transmitted light, a pale greenish yellow colour, and, by reflected light, an intense yellowish-green fluorescence which disappears on the addition of mineral acids or alkalis.

Specific optical rotation: -115 to -135 (dried substance).
Dissolve 50.0 mg in 0.05 M sodium hydroxide free from carbonate and dilute to 10.0 mL with the same alkaline solution. Measure the optical rotation within 30 min of dissolution.
Test solution Dilute the final solution prepared for the assay with an equal volume of water.
Absorption maxima at 223 nm, 267 nm, 373 nm and 444 nm.
Absorbance ratios:
— A373/A267 = 0.31 to 0.33;
— A444/A267 = 0.36 to 0.39.
Related substances: To pass the test.
Loss on drying: Maximum 1.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on the residue obtained in the test for loss on drying.

Riboflavin FCC Food Grade Specifications:
Vitamin B2
C17H20N4O6 Formula weight 376.37
INS: 101(i) CAS 83-88-5

Riboflavin occurs as a yellow to orange-yellow, crystalline powder. When dry, it is not affected by diffused light, but when in solution, light induces deterioration. It melts at about 280° with decomposition, and its saturated solution is neutral to litmus. One-gram dissolves in 3000 to about 20,000 mL of water, the variations being due to differences in the internal crystalline structure. It is less soluble in alcohol than in water. It is insoluble in ether and in chloroform, but it is very soluble in dilute solutions of alkalis.
Function: Nutrient.

Identification: A solution of 1 mg of sample in 100 mL of water is pale green-yellow by transmitted light and has an intense yellow-green fluorescence that disappears on the addition of mineral acids or alkalies.
Assay: Not less than 98.0% and not more than 102.0% of C17H20N4O6, calculated on the dried basis.
Loss on Drying: Not more than 1.5%.
Lumiflavin: Passes test.
Optical (Specific) Rotation: [α]D25°: Between +56.5° and +59.5°, calculated on the dried basis.
Residue on Ignition: Not more than 0.3%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

Vitamin A or Retinol

Ascorbic Acid, Vitamin C

Cholecalciferol or Vitamin D3

D-Biotin, Vitamin B7 or H

Niacin or Nicotinic Acid Vitamin B3

Nicotinamide or Niacinamide Vitamin B3

Rutin Trihydrate or Vitamin P

Thiamine Hydrochloride or Vitamin B1

Riboflavin or Vitamin B2

Pyridoxine Hydrochloride or Vitamin B6.


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Last 13 May, 2024

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Riboflavin or Vitamin B2 SDS Sheet, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet

1. Product Identification

Product Name & Other Names: Riboflavin or Vitamin B2.
CAS No.: 83-88-5
EINECS EC Code: 201-507-1
Molecular Weight: 376.36
Chemical Formula: C17H20N4O6
Relevant uses and uses advised against (if any): Industrial Manufacturing.
SUPPLIER: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: None

Hazards not otherwise classified (HNOC):
May cause mild skin irritation.
May cause mild eye irritation.
May cause mild respiratory irritation.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

3. Composition/Information on Ingredients

Product Name & Other Names: Riboflavin or Vitamin B2.
CAS No.: 83-88-5
EINECS EC Code: 201-507-1

4. First Aid Measures

Always seek medical advice after the first aid treatment.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact medical center quickly. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Check for and remove any contact lenses. Immediately flush your eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Get medical attention.

5. Fire Fighting Measures

Combustible at high temperature. High heat or direct flame is necessary to cause ignition. Toxic fumes, carbon monoxide and nitrogen oxides may be formed in fire.
Explosion: At high temperature, explosive vapor-air mixtures may be formed.
Fire Extinguishing Media: Dry chemical, foam, water spray or carbon dioxide. Do not use a solid stream of water since the stream will scatter and spread the fire. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Mop and pick up the material and place in an appropriate waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Avoid dust formation. Keep away from heat. Keep away from sources of ignition. Provide ventilation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Keep away from heat and source of fire. Store in cold, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not breathe dust. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like oxidizing material. Storage: Room temperature. Preferably refrigerate. In a light resistance container.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to the substance is apparent and engineering controls are not feasible, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-face piece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron, or coveralls, as appropriate, to prevent skin contact.
Eye Protection: Use chemical safety goggles and/or a full-face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: Orange yellow crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: 5.5 - 7.2 for 0.07 g/l in water @ 20C.
Melting point: 280C to 290C literature..
Boiling point: 710C (Predicted).
Relative density: 1.65 (Predicted).
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Very slightly soluble in water.
Viscosity: Not available.
Molecular Weight: 376.36
Chemical Formula: C17H20N4O6

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides and toxic fumes may form when heated to decomposition.
Hazardous Polymerization: Not reported. However, it can explode under certain conditions.
Incompatibilities: Strong oxidizing agents, heat, and sparks.
Conditions to Avoid: Heat, flames, sunlight, ignition sources and incompatibles.

11. Toxicological Information

LD50 Oral - Rat - >10000 mg/kg.
LC50 Inhalation - Rat - 4 h: >5.4 mg/l - dust/mist.
Carcinogenicity: No component of this product present at levels greater than or equal to 0.1% is identified as possible or confirmed human carcinogen by IARC, ACGIH, OSHA and NTP.
Teratogenic Effects: Not available.
Mutagenic Effects: Not available.
Developmental Toxicity: Not available.
Reproductive Effects: No information available.

12. Ecological Information

Toxicity to fish: static test LC50 - Danio rerio (zebra fish) - > 10.000 mg/l - 96 h
Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna (Water flea) - > 47,4 mg/l - 48 h.
Mobility: No data available.
Biodegradability: Expected to be biodegradable
Results of PBT and vPvB assessment
: No data available for assessment.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

14. Transport Information

DOT USA & ADR/RID Europe: Not regulated.
IMDG/IMO: Not regulated.
IATA/ICAO: Not regulated.

15. Regulatory Information

SARA 311/312 Hazards
: See section 2.
California Prop. 65 Components: This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

16. Other Information

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.