Sodium monofluorophosphate USP Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Sodium monofluorophosphate, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Sodium monofluorophosphate: CAS Number: 10163-15-2, EINECS EC Number: 233-433-0, Molecular Formula: Na2PFO3, Molecular Weight: 143.95, HS Code ---**

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For SDS MSDS Sheet Click
SDS MSDS Sheet of Sodium monofluorophosphate Manufacturers

Sodium monofluorophosphate
Pure USP Grade Suppliers
Sodium monofluorophosphate

Sodium monofluorophosphate or MFP also known as Sodium fluorophosphate, Disodium monofluorophosphate, is an inorganic compound with the chemical formula Na2PO3F. MFP is odorless, colorless, and water-soluble. This salt is an ingredient in some toothpastes. Sodium monofluorophosphate in toothpaste safely and effectively helps to prevent tooth decay. Sodium monofluorophosphate is recognized by the United States Food and Drug Administration (FDA) and the European Community (EC)  as safe and effective as an anti-cavity agent in oral care products.

Specifications of Sodium Monofluorophosphate USP Grade:
Na2PFO3 143.95
Phosphorofluoridic acid, disodium salt.
Disodium phosphorofluoridate [CAS 10163-15-2].

Sodium Monofluorophosphate contains not less than 91.7 percent and not more than 100.5 percent of Na2PFO3, calculated on the dried basis.

Packaging and storage: Preserve in well-closed containers.
A: Place about 1 g in a platinum crucible in a well-ventilated hood and add 15 mL of sulfuric acid. Cover the crucible with a piece of clear, polished glass, and heat on a steam bath for 1 hour. Remove the glass cover, rinse it in water, and dry: the glass surface exposed to vapors from the crucible is etched.
B: A solution (1 in 10) with silver nitrate yields a white precipitate, which is soluble in diluted nitric acid and in dilute ammonium hydroxide (1 in 2).
C: A solution responds to the tests for Sodium.
pH: between 6.5 and 8.0, in a solution (1 in 50).
Loss on drying: Dry it at 105C to constant weight: it loses not more than 0.2% of its weight.
Arsenic: 3 ppm.
Heavy metals: Dissolve 400 mg in 25 mL of water: the limit is 0.005%.
Limit of fluoride ion: [NOTE—Use plasticware throughout this test.]
Buffer solution: To 55 g of sodium chloride in a 1000-mL volumetric flask add 500 mg of sodium citrate, 255 g of sodium acetate, and 300 mL of water. Shake to dissolve, and cautiously add 115 mL of glacial acetic acid with mixing. Cool to room temperature, add 300 mL of isopropyl alcohol, dilute with water to volume, and mix: the pH of this solution is between 5.0 and 5.5.
Standard stock solution: Dissolve an accurately weighed quantity of USP Sodium Fluoride quantitatively in water to obtain a solution containing 1105 micro-gm per mL. Each mL of this solution contains 500 micro-gm of fluoride ion. Store in a tightly closed, plastic container.
Standard preparations: To four 100-mL volumetric flasks transfer, respectively, 2.0-, 4.0-, 10.0-, and 20.0-mL portions of the Standard stock solution, dilute each with Buffer solution to volume, and mix to obtain solutions having fluoride ion concentrations of 10, 20, 50, and 100 micro-gm per mL, respectively.
Test preparation: Transfer about 1.8 g, accurately weighed, to a 100-mL volumetric flask, add water to dissolve, dilute with water to volume, and mix. Transfer 20.0 mL of this solution to a second 100-mL volumetric flask, dilute with Buffer solution to volume, and mix.
Procedure: Concomitantly measure the potential in mV, of the Standard preparations and of the Test preparation with a pH meter capable of a minimum reproducibility of ±0.2 mV, equipped with a glass-sleeved calomel-fluoride specific-ion electrode system. [NOTE: When taking measurements, immerse the electrodes in the solution, which has been transferred to a 150-mL plastic beaker containing a plastic-coated stirring bar. Allow to stir on a magnetic stirrer having an insulated top until equilibrium is attained (1 to 2 minutes), and record the potential. Rinse and dry the electrodes between measurements, taking care to avoid damaging the crystal of the specific-ion electrode.] Plot the logarithm of the fluoride-ion concentrations, in micro-gm per mL, of each Standard preparation versus potential, in mV. From the measured potential of the Test preparation and the standard curve, determine the concentration, in micro-gm per mL, of fluoride ion in the Test preparation: not more than 1.2% is found.
Monochloroacetate buffer: Dissolve 189 g of monochloroacetic acid and 55 g of sodium hydroxide in about 1500 mL of water. Cool, dilute with water to 2000 mL, and mix.
0.025 M Thorium nitrate: Dissolve 13.8 g of thorium nitrate in about 800 mL of water, and filter the solution into a 1000-mL volumetric flask. Dilute with water to volume, and mix. Standardize this solution as follows. Transfer 20.0 mL of Standard stock solution, prepared as directed in the test for Limit of fluoride ion, to a 150-mL beaker containing 50 mL of water. Add 3 drops of sodium alizarinsulfonate, mix, and adjust the acidity by the careful addition, successively, of sodium hydroxide solution (1 in 50) and dilute hydrochloric acid (1 in 160), until the pink color has just been discharged. Add 1 mL of Monochloroacetate buffer, and titrate with 0.025 M Thorium nitrate to a permanent pink color. Calculate the molarity of the thorium nitrate titrant taken by the equation: M = (S) / [(4)(41.99V)] in which S is the weight, in mg, of USP Sodium Fluoride RS in the portion of Standard stock solution taken, 41.99 is the molecular weight of sodium fluoride, and V is the volume, in mL, of titrant consumed.
Procedure: Transfer about 1.8 g of Sodium Monofluorophosphate, accurately weighed, to a 100 mL volumetric flask. Add about 50 mL of water, mix to effect solution, dilute with water to volume, and mix. Transfer 20.0 mL of this solution to the reaction flask of a suitable fluoride steam distilling apparatus containing 10 lime-glass beads measuring 5 mm in diameter and 70 mL of dilute sulfuric acid (1 in 2). Distil, by passing steam through the solution in the reaction flask and applying heat to the flask, collecting the distillate in a 250-mL volumetric flask. Control the temperature of the solution in the reaction flask so that it does not exceed 140C. Change receivers when the flask is filled to volume with distillate, and continue distilling into a 400-mL beaker until an additional 150 mL to 200 mL of distillate tailing has been collected. Mix the solution in the 250-mL volumetric flask, and transfer 50.0 mL to a 150-mL beaker. To the 150-mL beaker add 50 mL of water and 3 drops of sodium alizarinsulfonate, and mix. Adjust the acidity of this solution by the careful addition, successively, of sodium hydroxide solution (1 in 50) and dilute hydrochloric acid (1 in 160), until the pink color has just been discharged. Add 1 mL of Monochloroacetate buffer, titrate with 0.025 M Thorium nitrate to a permanent pink color, and record the volume, in mL, of titrant consumed as VA. Add 3 drops of sodium alizarinsulfonate TS to the distillation tail in the 400-mL beaker, proceed as directed previously with the adjustment of the acidity, the addition of Monochloroacetate buffer, and the titration with 0.025 M Thorium nitrate, and record the volume, in mL, of titrant consumed as VB. Calculate the percentage of Na2PFO3 in the Sodium Monofluorophosphate taken by the formula: [(2)(143.95)(5VA + VB)(M) / (W)] (143.95 / 18.9984)(F) in which M is the molarity of 0.025 M Thorium nitrate; W is the weight, in g, of the Sodium Monofluorophosphate taken; F is the percentage of fluoride ions determined as directed in the test for Limit of fluoride ion; 143.95 is the molecular weight of sodium monofluorophosphate; 18.9984 is the atomic weight of fluorine; and the other terms are as defined therein.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:


Ethyl Trifluoroacetate


Sodium Silico Fluoride

Sodium Monofluorophosphate

Trifluoroacetic Acid or TFA.


Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
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Last 30 November, 2023

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Sodium monofluorophosphate SDS, Safety Data Sheet
MSDS Sheet, Material
Safety Data Sheet 18-Nov-20

1. Product Identification

Product Name & Other Names: Sodium monofluorophosphate or MFP also known as Sodium fluorophosphate, Disodium monofluorophosphate.
CAS No.: 10163-15-2
EINECS EC Number: 233-433-0
Molecular Weight: 143.95
Chemical Formula: Na2PFO3
Relevant uses and uses advised against (if any): Industrial Manufacturing
Supplier: As per letterhead.

2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910

Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4 (H302)

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements

Signal Words: warning

Hazard statements:
H302 Harmful if swallowed.

Precautionary statements:
P264: Wash … thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P330: Rinse mouth.
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352: IF ON SKIN: Wash with soap and water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P362: Take off contaminated clothing and wash before reuse.
P391: Collect spillage.
P405: Store in a closed container.
P501 Dispose of contents/ container to an approved waste disposal plant

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn = Harmful
Risk Phrase:
R22 = Harmful if swallowed.

3. Composition/Information on Ingredients

Product Name & Other Names: Sodium monofluorophosphate or MFP also known as Sodium fluorophosphate, Disodium monofluorophosphate.
CAS No.: 10163-15-2
EINECS EC Number: 233-433-0

4. First Aid Measures

Always seek medical attention after first aid measures are provided.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Contact a poison control center or physician for treatment advice. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Flammability of the Product: Non-flammable.
Flash Points: Not applicable.
Products of Combustion: During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Hydrogen fluoride, Sodium oxides, and phosphorous compounds can be formed.
Fire: Not considered to be a fire hazard.
Fire Extinguishing Media: Use water spray or fog for cooling exposed containers. Fine water spray, normal foam, dry agent (carbon dioxide, dry chemical powder) can be used. Exercise caution when fighting any chemical fire. Avoid (reject) fire-fighting water to enter environment.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

6. Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Avoid touching the spilled material. Do not let the product enter drains. Use a shovel to put the material into a convenient waste disposal container. Do not contaminate the environment.

7. Handling and Storage

Precautions for safe handling: Toxic if swallowed. Do not ingest. Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Provide appropriate exhaust ventilation at places where dust is formed. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatibles like oxidizing agents.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: ACGIH TLV, OSHA PEL & NIOSH IDLH Permissible 2.5 mg/m3 TWA (dust and mist, as F).
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: White solids, powder.
Odor: It is odorless.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Boiling Point: Not available.
Melting Point: 625C literature.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: It is freely soluble in water.
Viscosity: Not available.
Molecular Weight: 143.95
Chemical Formula: Na2PFO3

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Oxides of sodium and hydrofluoric acid fumes. Phosphorous compounds may form.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents. Slightly reactive to reactive with moisture
Conditions to Avoid: Incompatibles and moisture. Avoid Heat, Moisture & incompatibles.

11. Toxicological Information

Toxicity data
LD50 Oral - Rat - 502 - 638 mg/kg
LC50 Inhalation - Rat - male and female - 4 h - > 2,1 mg/l.
Carcinogenic Effects: Not known to be a carcinogen by IARC NTP ACGIH OSHA.
Mutagenic Effects: Not available.
Teratogenic Effects: Not available.
Developmental Toxicity: Not available.

12. Ecological Information

Toxicity to fish: semi-static test LC50 Oncorhynchus mykiss (rainbow trout) > 100 mg/l  - 96 h.
Toxicity to daphnia and other aquatic invertebrates: Immobilization EC50 - Daphnia magna (Water flea) - > 100 mg/l  - 48 h.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.

13. Disposal Considerations

This product is a registered pesticide. Pesticide wastes are acutely hazardous. Improper disposal is a violation of Law. Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Dispose of container and unused contents in accordance with federal, state and local requirements.

14. Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods.
IATA: Not dangerous goods.
: Not dangerous goods.

15. Regulatory Information

SARA 311/312
: Acute Health Hazard. See section 2.
SARA 313 Components: Not applicable

16. Other Information

Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.