Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride CAS Number 67-03-8, EINECS EC Number: 200-641-8, Molecular Formula: C12H17N4OSCl-HCl, Molecular Weight: 337.27, HS Code 29362210

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SDS MSDS Sheet of Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride Manufacturers

Thiamine Hydrochloride
Vitamin B1 Hydrochloride or Aneurine Hydrochloride USP BP Ph Eur FCC Food Grade Suppliers
Thiamine Hydrochloride or Vitamin B1 Hydrochloride

General Properties and Specifications of Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride:
Appearance: White to off-white crystalline powder.
Solubility of 10% aq. solution: Clear.
Assay: 98.5% minimum.
pH: 2.7 - 3.3 of 2.5% aq. solution.
Loss on drying: 5% maximum.
Sulfated Ash: max. 0.1% maximum.
Heavy Metals (Pb): 0.001% maximum.
Melting Point: 250C (decomposes).
Solubility: Soluble in water.
Storage: Room temperature.


Thiamine Hydrochloride USP Grade Specifications:
C12H17ClN4OS-HCl -- 337.27
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride, monohydrochloride;
Thiamine monohydrochloride CAS67-03-8
UNII: M572600E5P
UNII: X66NSO3N35

DEFINITION
Thiamine Hydrochloride contains NLT 98.0% and NMT 102.0% of thiamine hydrochloride (C12H17ClN4OS ·HCl), calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption.
B. Identification Tests—General, Chloride: A 20-mg/mL solution meets the requirements.
Residue on Ignition: NMT 0.2%
Limit of Nitrate:
Sample solution: 20 mg/mL of Thiamine Hydrochloride
Analysis: To 2 mL of the Sample solution add 2 mL of sulfuric acid. Cool, and superimpose 2 mL of ferrous sulfate TS.
Acceptance criteria: No brown ring is produced at the junction of the two layers.
Related Compounds: To pass the chromatographic test.
pH: 2.7 to 3.4 in 10-mg/mL solution.
Water Determination: NMT 5.0%
Absorbance of Solution: To pass the test.


Thiamine Hydrochloride BP Ph Eur Grade Specifications:
C12H18Cl2N4OS --- 337.3 CAS 67-03-8

DEFINITION
3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride hydrochloride.
Content: 98.5 per cent to 101.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Freely soluble in water, soluble in glycerol, slightly soluble in ethanol (96 per cent), practically insoluble in heptane.

IDENTIFICATION
First identification: A, C
Second identification: B, C
A. Infrared absorption spectrophotometry.
B. Dissolve about 20 mg in 10 mL of water, add 1 mL of dilute acetic acid and 1.6 mL of 1 M sodium hydroxide, heat on a water-bath for 30 min and allow to cool. Add 5 mL of dilute sodium hydroxide solution, 10 mL of potassium ferricyanide solution and 10 mL of butanol and shake vigorously for 2 min. The upper alcoholic layer shows an intense light-blue fluorescence, especially in ultraviolet light at 365 nm. Repeat the test using 0.9 mL of 1 M sodium hydroxide and 0.1 g of anhydrous sodium sulfite instead of 1.6 mL of 1 M sodium hydroxide. Practically no fluorescence is seen.
C. It gives reaction of chlorides.

TESTS
Solution S: Dissolve 2.5 g in carbon dioxide-free water and dilute to 25 mL with the same solvent.
Appearance of solution: The solution is clear and not more intensely coloured than reference solution
pH: 2.7 to 3.3.
Related substances: To pass the test.
Sulfates: Maximum 300 ppm.
Water: Maximum 5.0 per cent, determined on 0.400 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.


Thiamine Hydrochloride FCC Food Grade Specifications:
Aneurine Hydrochloride; Thiamine Chloride; Vitamin B1;
Vitamin B1 Hydrochloride
C12H17ClN4OS-HCl Formula weight 337.27
CAS 67-03-8

DESCRIPTION
Thiamine Hydrochloride occurs as small, white to yellow-white crystals or crystalline powder. When exposed to air, the anhydrous product rapidly absorbs about 4% of water. It melts at about 248C with some decomposition. One-gram dissolves in about 1 mL of water and in about 100 mL of alcohol. It is soluble in glycerin and is insoluble in ether.
Function: Nutrient.

Identification
A. The infrared absorption spectrum of a potassium bromide dispersion of the sample, previously dried at 105C for 2 h, exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Thiamine Hydrochloride Reference Standard.
B. A 1:50 aqueous solution gives positive tests for Chloride,

Assay: Not less than 98.0% and not more than 102.0% of C12H17ClN4OS·HCl, calculated on the anhydrous basis.
Color of Solution: Passes test.
Lead: Not more than 2 mg/kg.
Nitrate: Passes test.
pH of a 1:100 Solution: Between 2.7 and 3.4.
Residue on Ignition: Not more than 0.2%.
Water: Not more than 5.0%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

We also manufacture and supply as under:

Ascorbic Acid, Vitamin C

Beta-Carotene or β-Carotene

Biotin or D-Biotin or Vitamin B7 or Vitamin H

Calamine

L-Carnitine or Vitamin BT or Levocarnitine

Cholecalciferol or Vitamin D3

Cyanocobalamin

Aminoethyl Ethanolamine

Hydroxylamine Hydrochloride

Methoxylamine hydrochloride

Niacin or Nicotinic Acid Vitamin B3

Nicotinamide or Niacinamide Vitamin B3

Pyridoxine Hydrochloride or Vitamin B6

Riboflavin or Vitamin B2

Rutin Trihydrate or Rutoside or Vitamin P Trihydrate

Thiamine Hydrochloride or Vitamin B1

Thymidine.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

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Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Last 17 December, 2023

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Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride
SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet
25-Oct-23

1. Product Identification

Product Name & Other Names: Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride.
CAS No.: 67-03-8
EINECS, EC Number: 200-641-8
Molecular Weight: 337.27
Molecular Formula: C12H17N4OSCl-HCl
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Supplier: As per letterhead.

2. Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Serious eye damage/eye irritation Category 2A, H319

Labelling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Irritant
Irritant

Signal Words: Warning

Hazard statements:
H319: Causes serious eye irritation.

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36 Irritating to eyes.

3. Composition/Information on Ingredients

Product Name & Other Names: Thiamine Hydrochloride or Vitamin B1 Hydrochloride or Aneurine Hydrochloride.
CAS No.: 67-03-8
EINECS, EC Number: 200-641-8

4. First Aid Measures

Always seek medical attention after first aid measures are provided.

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

5. Fire Fighting Measures

Flammability of the Product: Combustible at high temperature..
Auto-Ignition Temperature: NA.
Flammable Limits: Not available.
Products of Combustion: Nitrogen oxides, Sulfur oxide, Carbon dioxide, Carbon monoxide, fumes.
Fire: Flammable in the presence of open flame.
Explosion: Slightly explosive in presence of heat.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Avoid heavy water jet. Use any means suitable for extinguishing surrounding fire.
Special Information: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures or when moistened under fire conditions, it may produce toxic or irritating fumes.

6. Accidental Release Measures

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

7. Handling and Storage

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: 30C maximum.

8. Exposure Controls/Personal Protection

Airborne Exposure Limits: Not Established.
Ventilation System
: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

9. Physical and Chemical Properties

Appearance: White to off-white crystalline powder.
Odor: Not available.
Odor threshold: Not available.
pH: 2.7 - 3.3 of 2.5% aq. solution.
Relative density: Not available.
Melting Point: 250C (decomposes).
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 337.27
Molecular Formula: C12H17N4OSCl-HCl

10. Stability and Reactivity

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits Oxides of Nitrogen and Sulfur, Carbon dioxide, Carbon monoxide & Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles, moisture, heat & direct sunlight.

11. Toxicological Information

Toxicity data: LD50 Oral - Mouse 13350 mg/kg.
Carcinogenic Effects: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible, or confirmed human carcinogen by IARC.
Reproductive toxicity: Not available.
Germ cell mutagenicity: Not available.

12. Ecological Information

Toxicity to fish: static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 100 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h.
Environmental Fate: Not available.
Environmental Toxicity: Not available.
Persistence and degradability: Unlikely to persist due to water solubility.
Bioaccumulative potential: Readily biodegradable.
Mobility in soil: Likely to be mobile due to water solubility.
Results of PBT and vPvB assessment: Not available.

13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of containers and unused contents in accordance with federal, state, and local requirements.

14. Transport Information

DOT USA, TDG Canada & ADR/RID Europe: Not regulated
IATA: Not regulated
IMDG/IMO: Not regulated.

15. Regulatory Information

USA:
SARA 311/312 Hazards
: Immediate Health Hazard. See section 2.
California prop. 65: Contains no chemical subject to California Prop 65.

Section 16 - Additional Information

European Labeling in Accordance with EC Directives:
H319 = Causes serious eye irritation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:

Hazard Symbol:
Xi Irritant
Risk Phrases:
R36/ Irritating to eyes.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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