Chlorbutol or Chlorobutanol hemihydrate or 1,1,1-Trichloro-2-methyl-2-propanol Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Chlorbutol or Chlorobutanol, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal, Bangladesh, etc.

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Chlorbutol or Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol: CAS Number: 57-15-8 and 6001-64-5 for hemihydrate, EINECS EC Number: 200-317-6 and 249-042-3 for hemihydrate, Molecular Formula: C4H7Cl3O and Cl3CC(CH3)2OH-0.5H2O for hemihydrate, Molecular Weight: 177.45 and 186.46 for hemihydrate, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Chlorbutol or Chlorobutanol hemihydrate or 1,1,1-Trichloro-2-methyl-2-propanol.

Chlorbutol or Chlorobutanol has preservative as well as antibacterial and antifungal activity. Apart from other uses, it is used for treatment of impacted ear wax. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity. It is used as is a preservative, sedative, hypnotic and weak local anesthetic.

Properties and General Specifications of Chlorbutol or Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol:
Appearance: Colorless to white crystals.
Assay: 99% minimum.
Odor: Camphor like odor.
Taste: Camphor like taste.
Melting point: 97 to 99C literature.
Boiling point: 167C literature.
Solubility: Soluble in water. Soluble in alcohol and glycerol, ether, chloroform.

Specifications of Chlorobutanol USP NF Grade:
C4H7Cl3O (anhydrous) --- 177.46
2-Propanol, 1,1,1-trichloro-2-methyl-.
1,1,1-Trichloro-2-methyl-2-propanol --- 57-15-8.
Hemihydrate --- 186.46 --- CAS 6001-64-5.

Chlorobutanol is anhydrous or contains not more than one-half molecule of water of hydration. It contains not less than 98.0 percent and not more than 100.5 percent of C4H7Cl3O, calculated on the anhydrous basis.
Packaging and storage: Preserve in tight containers.
Labeling: Label it to indicate whether it is anhydrous or hydrous.

Identification:
A: Infrared Absorption.
B: To 5 mL of a freshly prepared solution (1 in 200) add 1 mL of 1 N sodium hydroxide, then slowly add 3 mL of iodine: a yellow precipitate of iodoform, recognizable by its odor, appears.
Reaction: Shake thoroughly 0.5 g with 25 mL of water: the water remains neutral to litmus.
Water: not more than 1.0% (anhydrous form) and not more than 6.0% (hydrous form).
Chloride: To a solution of 0.50 g in a mixture of 25 mL of diluted alcohol and 1 mL of nitric acid add 2 mL of silver nitrate: any turbidity produced is not greater than that produced from a control solution containing 0.50 mL of 0.020 N hydrochloric acid in place of the Chlorobutanol (0.07%).
Assay:
Denatured alcohol: Dilute 100 mL of isopropyl alcohol to 1000 mL with alcohol.
Potassium hydroxide solution: Transfer 58 g of potassium hydroxide to a 1000-mL volumetric flask. Add 100 mL of water to dissolve, then cool the solution. Dilute with Denatured alcohol to volume, and mix. Prepare fresh just prior to use.
Procedure: Transfer about 100 mg of Chlorobutanol, accurately weighed, to a glass-stoppered, flat-bottomed boiling flask. Add 50 mL of Potassium hydroxide solution, attach the flask to a reflux condenser, and reflux for 1 hour. Allow the flask to cool while still attached to the condenser, then add 100 mL of water, using a portion of the water to rinse the condenser and its tip. Add 15 mL of nitric acid while stirring. Titrate with 0.1 N silver nitrate, determining the endpoint potentiometrically, using a silver-billet combination electrode, consisting of a metallic silver indicator electrode and a double junction reference electrode that allows use of a nonchloride filling solution (such as ammonium nitrate solution) for determining chloride, or equivalent. Perform a blank determination and make any necessary correction. Each mL of 0.1 N silver nitrate is equivalent to 5.915 mg of C4H7Cl3O.

Chlorobutanol Hemihydrate C4H7Cl3O-1/2H2O, CAS 6001-64-5 is generally prefered by the users

Chlorobutanol Hemihydrate BP Ph Eur Grade Specifications
C4H7Cl3O,½H2O --- 186.5 --- CAS 6001-64-5
Action and use: Disinfectant preservative.

DEFINITION
1,1,1-Trichloro-2-methylpropan-2-ol hemihydrate.
Content: 98.0 per cent to 101.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals, sublimes readily.
Solubility: Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
Melting point: About 78C (without previous drying).

IDENTIFICATION
A. Add about 20 mg to a mixture of 1 mL of pyridine and 2 mL of strong sodium hydroxide solution. Heat in a water-bath and shake. Allow to stand. The pyridine layer becomes red.
B. Add about 20 mg to 5 mL of ammoniacal silver nitrate solution and warm slightly. A black precipitate is formed.
C. To about 20 mg add 3 mL of 1 M sodium hydroxide and shake to dissolve. Add 5 mL of water and then, slowly, 2 mL of iodinated potassium iodide solution. A yellowish precipitate is formed.
D. Water (see Tests).

TESTS
Solution S: Dissolve 5 g in ethanol (96 per cent) and dilute to 10 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension and not more intensely coloured than reference solution.
Acidity: To 4 mL of solution S add 15 mL of ethanol (96 per cent) and 0.1 mL of bromothymol blue solution. Not more than 1.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue.
Chlorides: Maximum 100 ppm.
Water: 4.5 per cent to 5.5 per cent, determined on 0.300 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

ASSAY
Dissolve 0.100 g in 20 mL of ethanol (96 per cent). Add 10 mL of dilute sodium hydroxide solution, heat in a water-bath for 5 min and cool. Add 20 mL of dilute nitric acid, 25.0 mL of 0.1 M silver nitrate and 2 mL of dibutyl phthalate and shake vigorously. Add 2 mL of ferric ammonium sulfate solution and titrate with 0.1 M ammonium thiocyanate until an orange colour is obtained. 1 mL of 0.1 M silver nitrate is equivalent to 5.92 mg of C4H7Cl3O.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

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Chlorbutol or Chlorobutanol SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 09-Oct-20

Product Name & Other Names: Chlorbutol or Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol Hydrochloride.
CAS Number: 57-15-8 and 6001-64-5 for hemihydrate
EINECS EC Number: 200-317-6 and 249-042-3 for hemihydrate
Molecular Weight: 177.45 and 186.46
Chemical Formula: C4H7Cl3O and Cl3CC(CH3)2OH-0.5H2O for hemihydrate
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Acute toxicity, oral Category 4, H302
Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Specific target organ toxicity, single exposure; Narcosis Category 3, H336

Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H336: May cause drowsiness or dizziness.

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+ P352 - IF ON SKIN: Wash with plenty of soap and water.
P305+ P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn Harmful
Xi Irritant
Risk Phrase:
R22: Harmful if swallowed
R36/37/38: Irritating to eyes, respiratory system & skin.
R67 Vapors may cause drowsiness and dizziness.

Product Name & Other Names: Chlorbutol or Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol Hydrochloride.
CAS Number: 57-15-8 and 6001-64-5 for hemihydrate.

Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Remove contact lenses, if present and easy to do. Continue rinsing. Get medical attention.
Note to physicians: Treat symptomatically.

Fire: Not considered to be a fire hazard but it can burn at higher temperatures.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Carbon oxides, Hydrogen chloride gas and Toxic fumes.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece. Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used.

Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Ensure adequate ventilation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material. Entry to non-involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Do not let the product enter drains, soil or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Vacuum or sweep-up and remove to an approved disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat or smoke while handling. Avoid contact with skin, eyes and clothing. Minimize dust generation. Handling is performed in a well-ventilated place. Wear suitable protective equipment. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents, acids, acid chlorides, acid anhydrides. Avoid dust formation and control ignition sources. Containers of may be hazardous when empty.

Airborne Exposure Limits: None established. Ensure adequate ventilation. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: Colorless to white crystals.
Odor: Camphor like odor.
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 97 to 99C literature
Initial boiling point and boiling range: 167C literature.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water. Soluble in alcohol and glycerol, ether, chloroform.
Viscosity: Not available.
Molecular Weight: 177.45 and 186.46
Chemical Formula: C4H7Cl3O and Cl3CC(CH3)2OH-0.5H2O for hemihydrate.

Stability: Stable under ordinary conditions of use and storage. Hygroscopic.
Hazardous Decomposition Products: May produce Carbon oxides, Hydrogen chloride gas and Toxic fumes when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Conditions to Avoid: Heat, flame, moisture, ignition sources, dusting and incompatibles.

LD50 oral rat: 510 mg/kg.
LD50 dermal rat: >2000 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Mutagenic Effects: No information available
Reproductive Effects: No information available.
Developmental Effects: No information available.
Teratogenicity: No information available.

Toxicity to fish: No information available.
Persistence and Degradability: Soluble in water Persistence is unlikely.
Bioaccumulation/ Accumulation: No information available.
Mobility: Will likely be mobile in the environment due to its water solubility.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of container and unused product in accordance with legal requirements.

DOT USA: Not regulated
TDG: Not regulated
IATA: Not regulated
IMDG/IMO: Not regulated
ADR/RID Europe: Not regulated.

USA:
SARA 313: Not applicable
SARA 311/312 Hazardous Categorization: Acute Health Hazard.
California Proposition 65: This product does not contain any Proposition 65 chemicals.

European Labeling in Accordance with EC Directives:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
H336: May cause drowsiness or dizziness.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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