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Calcium Polystyrene Sulfonate BP Grade Manufacturers, SDS GHS MSDS Sheet

Calcium Polystyrene Sulfonate: CAS Number: CAS 37286-92-3., EINECS EC Number: yyyyy, Molecular Formula: C8H7CaO3S+, Molecular Weight: 223.3, HS Code ---**

For SDS MSDS Sheet Click
SDS MSDS Sheet of Calcium Polystyrene Sulfonate Manufacturers

Calcium Polystyrene Sulfonate
Pure BP Grade
Calcium polystyrene sulphonate

Typical Specifications of Calcium Polystyrene Sulfonate:
Characteristic: A cream to light brown fine powder, free from foreign particles.
Solubility: Practically insoluble in water and in 96% ethanol.
Identifications:
1) The IR spectrum of the sample should be concordant with reference spectrum of Calcium Polystyrene Sulphonate BP grade.
2) Gives characteristic of Calcium Salt.
Fineness: Not more than 1% is retained on 100 mesh BSS 150 micron sieve.
Potassium: <0.1%
Sodium: <0.1%
Arsenic: <1ppm
Heavy Metals: Not more than 10ppm
Styrene: <1ppm
Potassium Exchange Capacity: Each gram exchange not less than 1.3mEq and not more than 2 mEq calculated on dried basis.
Loss on Drying: <8%


Calcium Polystyrene Sulphonate BP
Action and use: Used in the treatment of hyperkalaemia.

DEFINITION
Calcium Polystyrene Sulphonate is a cation-exchange resin prepared in the calcium form containing not less than 6.5% w/w and not more than 9.5% w/w of calcium, calculated with reference to the dried substance. Each g exchanges not less than 1.3 mEq and not more than 2.0 mEq of potassium, calculated with reference to the dried substance.

CHARACTERISTICS
A cream to light brown, fine powder.
Practically insoluble in water and in ethanol (96%).

IDENTIFICATION
A. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of calcium polystyrene sulphonate.
B. Yields reaction C characteristic of calcium salts.

TESTS
Particle size: Not more than 1% w/w is retained on a 150-μm sieve. Use 20 g and sieve for 5 minutes.
Potassium: Not more than 0.1% of K when determined by atomic emission spectrophotometry.
Sodium: Not more than 0.1% of Na when determined by atomic emission spectrophotometry ,
Heavy metals: Heat 4 g until charred, cool, add 4 ml of lead-free nitric acid and 0.5 ml of sulphuric acid drop wise and heat cautiously until white fumes are no longer evolved. Ignite in a muffle furnace at 500C to 600C until a white residue is obtained. Cool, add 4 ml of hydrochloric acid and dilute to 20 ml. The resulting solution complies with limit test A for heavy metals, Appendix VII. Use 2 ml of lead standard solution (10 ppm Pb) to prepare the standard (10 ppm).
Styrene: Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) shake 10 g of the substance being examined with 10 ml of acetone for 30 minutes, centrifuge and use the supernatant liquid. Solution (2) contains 0.0001% w/v of styrene in acetone.
The chromatographic procedure may be carried out using (a) a stainless steel column (30 cm × 4 mm) packed with octadecylsilyl silica gel for chromatography (μBondapak C18 is suitable), (b) a mixture of equal volumes of acetonitrile and water as the mobile phase with a flow rate of 2 ml per minute and (c) a detection wavelength of 254 nm. Inject separately 20 μl of each solution. The area of the peak corresponding to styrene in the chromatogram obtained with solution (1) is not greater than the area of the principal peak in the chromatogram obtained with solution (2) (1 ppm).
Potassium exchange capacity: To 3 g of the substance being examined in a dry 250 ml glass-stoppered flask add 100 ml of a solution containing 0.7455% w/v of potassium chloride and 0.4401% w/v of potassium hydrogen carbonate in water (solution A), stopper and shake for 15 minutes. Filter and dilute 2 ml of the filtrate to 1000 ml with water. Determine the concentration of unbound potassium in this solution by atomic emission spectrophotometry , Appendix II D, measuring at 766.5 nm and using solution A suitably diluted with water, to prepare the standard solutions. Calculate the potassium exchange capacity of the substance being examined in milliequivalents taking the concentration of potassium in solution A as 144 milliequivalents of K per litre.
Loss on drying: When dried at 70C at a pressure not exceeding 0.7 kPa for 16 hours, loses not more than 8.0% of its weight. Use 2 g.
Microbial contamination: Carry out a quantitative evaluation for Enterobacteria and certain other Gram-negative bacteria, Appendix XVI B1. 0.01 g of the substance being examined gives a negative result, Table I (most probable number of bacteria per gram fewer than 100).

ASSAY
For calcium: Carefully heat 1 g in a platinum crucible until a white ash is obtained and dissolve in 10 ml of 2 M hydrochloric acid with the aid of heat. Transfer the resulting solution to a conical flask using 20 ml of water. Add 50 ml of 0.05 M disodium edetate, 20 ml of ammonia buffer pH 10.9 and titrate the excess of disodium edetate with 0.02 M zinc sulphate, using a 0.5% w/v solution of mordant black 11 in ethanol (96%) as indicator to a red purple end point.
Each ml of 0.05 M disodium edetate VS is equivalent to 2.004 mg of Ca.

STORAGE
Calcium Polystyrene Sulphonate should be kept in an airtight container.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) 91-22-23770100, 23726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA & Canadian Customers may
e-mail: usa@mubychem.com
Call toll-free 1-844-682-9243 (1-844-MUBYCHEM)

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Last 8 August, 2017

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Calcium Polystyrene Sulphonate SDS MSDS Sheet, Material Safety Data Sheet

Section 1: Chemical Product and Company Identification

Product Name: Calcium Polystyrene Sulfonate
CAS #
: 37286-92-3
Relevant Uses: Industrial use only.
Supplier: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.

Labeling according to GHS & Regulation (EC) No 1272/2008

GHS Label Elements
NONE

Signal Word: None

Hazards not otherwise classified (HNOC):
The toxicological properties of this material have not been fully investigated.
May causes mild skin irritation.
May causes mild eye irritation.
May cause irritation of digestive tract.
May cause irritation of respiratory tract.

Precautionary statements:
P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P262: Do not get in eyes, on skin, or on clothing.
P281: Use personal protective equipment as required.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P303+P361+P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+313: If eye irritation persists get medical advice/attention.

Section 3: Composition and Information on Ingredients

Product Name: Calcium Polystyrene Sulfonate
CAS #
: 37286-92-3
% by Weight: 90-100%. Mainly water as other substance.

Section 4: First Aid Measures

Always seek medical advice after the first aid treatment.
FIRST AID: CALL A PHYSICIAN. SKIN: Wash exposed area with soap and water.
EYES: Wash eyes with plenty of water for at least 15 minutes, lifting lids occasionally. Seek Medical Aid.
INHALATION: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
INGESTION: If swallowed, induce vomiting immediately after giving two glasses of water. Never give anything by mouth to an unconscious person.

Section 5: Fire and Explosion Data

Flammability of the Product: Non-flammable.
Products of Combustion: Calcium oxide with oxides of sulphur, carbon and fumes.
Extinguisher Media: Use media suitable to extinguish surrounding fire. Use alcohol-resistant foam, dry chemical or carbon dioxide.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of Calcium Polystyrene Sulfonate according to legal requirements.
Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions: Do not breathe dust. Keep away from incompatibles, oxidizing agents, acids.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Keep in original containers and avoid contact with moisture.

Section 8: Exposure Controls/Personal Protection

Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent Gloves.

Section 9: Physical and Chemical Properties

Physical state and appearance: Cream to light brown solid.
Odor: Not available.
Taste: Not available.
Molecular Weight: 172.17 g/mole
Color: Colorless. White.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Not available.
Specific Gravity: 0.7 to o.8 (Water = 1)
Solubility: In soluble in cold water and alcohol.

Section 10: Stability and Reactivity Data

Stability: Calcium Polystyrene Sulfonate is stable.
Conditions of Instability: Incompatible materials
Incompatibility with various substances: Reactive with oxidizing agents.
Corrosivity: Non-corrosive in presence of glass.
Polymerization: Will not occur.

Section 11: Toxicological Information

Toxicity to Animals:
LD50 (Oral) Rat >5000 mg/kg

Section 12: Ecological Information

Ecotoxicity: The product is not expected to be harmful to marine life.
Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Section 13: Disposal Considerations

Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information

DOT (US) & ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods

Section 15: Other Regulatory Information

USA Regulations:
OSHA Hazards: No known OSHA hazards
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

Section 16 - Additional Information

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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