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Hydroxyurea or Hydroxycarbamide Manufacturers, SDS GHS MSDS Sheet

Hydroxyurea or Hydroxycarbamide: CAS Number: 127-07-1, EINECS EC Number: 204-821-7, Molecular Formula: CH4N2O2, Molecular Weight: 76.05, HS Code ---**

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SDS MSDS Sheet of Hydroxyurea or Hydroxycarbamide Manufacturers

Hydroxyurea
Hydroxycarbamide
Hydroxyurea Hydroxycarbamide

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera.

Hydroxycarbamide BP Grade
Ph Eur

DEFINITION
N-Hydroxyurea
Content: 97.5 per cent to 102.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder, hygroscopic.
Solubility: Freely soluble in water, practically insoluble in alcohol. It shows polymorphism.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Examine the chromatograms obtained in the test for urea.

TESTS
Urea: Thin-layer chromatography.
Chlorides: Maximum 50 ppm.
Heavy metals: Maximum 10 ppm.
Water:  Maximum 0.5 per cent, determined on 2.00 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.


Hydroxyurea USP Grade
CH4N2O2 76.05
Urea, hydroxy-.
Hydroxyurea [127-07-1].
Hydroxyurea contains not less than 97.0 percent and not more than 103.0 percent of CH4N2O2, calculated on the dried basis.

Identification: Infrared Absorption 197K.
Loss on drying: Dry it in vacuum at 60 for 3 hours: it loses not more than 1.0% of its weight.
Residue on ignition: not more than 0.50%.
Heavy metals: not more than 0.003%.
Urea and related compounds: To pass the test.

Manufacturers:

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) 91-22-23770100, 23726950
Current Date Time in India GMT+5:30

e-mail: info@mubychem.com

USA & Canadian Customers may
e-mail: usa@mubychem.com
Call toll-free 1-844-682-9243 (1-844-MUBYCHEM)

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Copyright and Usual Disclaimer is Applicable.
Last 19 December, 2017

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Exporters to USA Canada UAE Europe South Africa Tanzania Kenya Uganda Egypt Nigeria Turkey Mexico Brazil Argentina Chile Dubai etc.

Global or International Suppliers, Exporters, Importers, Manufacturers

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Hydroxyurea or Hydroxycarbamide SDS MSDS Sheet, Material Safety Data Sheet

Section 1. Product Information

Product Name/Trade Name: Hydroxyurea or Hydroxycarbamide.
CAS No.: 127-07-1
EINECS EC Number: 204-821-7
Chemical Formula: CH4N2O2
Molecular Weight: 76.05
Recommended usage: Industrial Manufacturing.
Suppliers: As per letterhead.

Section 2: Hazards Identification

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Germ cell mutagenicity Category 1A, 1B, H340
Reproductive toxicity Category 2 H361

Labeling according GHS & Regulation (EC) No 1272/2008

GHS Label Elements
Health Hazard
Health Hazard

Signal Words: Danger

Hazard statements:
H340 May cause genetic defects.
H361 Suspected of damaging fertility or the unborn child.

Precautionary statements: P201, P202, P281, P308+P313, P405, P501
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulation.

Section 3: Composition and Information on Ingredients

Product Name/Trade Name: Hydroxyurea or Hydroxycarbamide.
CAS No.: 127-07-1
EINECS EC Number: 204-821-7

Section 4. First Aid & Procedure

Always get medical attention after the first aid is over.

Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin:
Immediately flush skin with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and shoes before reuse. Get medical attention if irritation develops.
Eyes:
Immediately flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. Hold eyelids apart during irrigation. Get medical attention.
Inhalation:
Remove person to fresh air. If breathing is difficult, give oxygen. If not breathing administer artificial respiration. Get medical attention.

Section 5. Fire Fighting Measures

Flash Point: N/A
Fire/Explosion:
Not considered to be a fire and explosion hazard.
Extinguishing Medium:
Water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Carbon oxides & Nitrogen oxides may evolve.
Fire Fighting Instructions: Use suitable protective equipment for surrounding fire.

Section 6. Spills and Disposals

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Avoid dust formation. Avoid breathing vapors, dust/mist or gas. Ensure adequate ventilation. Don't touch or walk through this product. Stop leak if safe to do so. Prevent entry into waterways, drains, confined areas. Prevent dust cloud. Collect material and place it into loosely covered plastic containers for later disposal.

Section 7. Handling and Storage

Handling: Wash hands before eating. Use with adequate ventilation. Avoid breathing dust. Avoid contacting skin, eyes and clothing. Avoid prolonged or repeated exposure.
Storage:
Keep in a tightly closed container and store in a cool, dry, well ventilated place. Protect against physical damage. Isolate from all incompatible substances. Recommended storage temperature 2 - 8 ┬░C

Section 8. Exposure Controls & Personal Protection

Exposure Limits: No data available.
Engineering Controls: Use adequate exhaust ventilation to keep airborne concentrations below the allowable exposure limit.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles.
Skin: Wear appropriate protective gloves.
Respiratory System: Approved or certified respirators.
Other Protective Equipments: Overalls or similar protective apparel, clean up facilities.
Don't eat, drink or smoke in work areas. Wash hands thoroughly after handling this material.

Section 9. Physical & Chemical Data

Physical State: Solid Powder.
Odor: None
Specific Gravity: No data available
pH Value:
No data available
Melting Point:
135C
Solubility in water: Soluble
Chemical Formula: CH4N2O2
Molecular Weight: 76.05

Section 10. Stability and Reactivity

Chemical Stability: Stable under recommended temperatures and pressures.
Incompatibility (Materials to Avoid):
Oxidizing agents.
Conditions to Avoid: Incompatible materials, exposure to moist air or water, excessive heat.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides.
Hazardous Polymerization:
Will not occur.

Section 11. Toxicological Information

Toxicity to Animals: LD50 Oral - Rat - 5,760 mg/kg for anhydrous material.
Carcinogenicity: IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydroxyurea).
Specific target organ toxicity: May cause damage to organs through prolonged or repeated exposure. Overexposure may cause reproductive disorder(s). May cause congenital malformation in the fetus. Suspected human reproductive toxicant. Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.

Section 12. Ecological Information

Ecotoxicity: No data available.
Persistence and Degradability: No data available.
Mobility in Soil: No data available.
Environmental Precautions: DO NOT DISCHARGE into drains and rivers.

Section 13. Disposal Suggestions

Dispose of in accordance with all applicable local, state and federal regulations at an approved waste disposal facility.

Section 14. Transport and Label Information

DOT (USA) & ADR/RID: Not dangerous goods
IMDG/IMO: Not dangerous goods
IATA: Not dangerous goods

Section 15. Regulatory Information

USA:
SARA 302
: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312: Chronic Health Hazard.
California Prop.65: WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. Hydroxyurea.

Section 16. Other Information

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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