Hydroxyurea or Hydroxycarbamide Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Hydroxyurea or Hydroxycarbamide, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Hydroxyurea or Hydroxycarbamide: CAS Number: 127-07-1, EINECS EC Number: 204-821-7, Molecular Formula: CH4N2O2, Molecular Weight: 76.05, HS Code ---**

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Hydroxyurea or Hydroxycarbamide.

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera.

DEFINITION
N-Hydroxyurea
Content: 97.5 per cent to 102.0 per cent (anhydrous substance).

CHARACTERS
Appearance: White or almost white, crystalline powder, hygroscopic.
Solubility: Freely soluble in water, practically insoluble in alcohol. It shows polymorphism.

IDENTIFICATION
A. Infrared absorption spectrophotometry.
B. Examine the chromatograms obtained in the test for urea.

TESTS
Urea: Thin-layer chromatography.
Chlorides: Maximum 50 ppm.
Heavy metals: Maximum 10 ppm.
Water: Maximum 0.5 per cent, determined on 2.00 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Hydroxyurea USP Grade
CH4N2O2 76.05
Urea, hydroxy-.
Hydroxyurea [CAS 127-07-1].
Hydroxyurea contains not less than 97.0 percent and not more than 103.0 percent of CH4N2O2, calculated on the dried basis.

Identification: Infrared Absorption 197K.
Loss on drying: Dry it in vacuum at 60 for 3 hours: it loses not more than 1.0% of its weight.
Residue on ignition: not more than 0.50%.
Heavy metals: not more than 0.003%.
Urea and related compounds: To pass the test.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
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Hydroxyurea or Hydroxycarbamide SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 23-Oct-20

Product Name/Trade Name: Hydroxyurea or Hydroxycarbamide.
CAS No.: 127-07-1
EINECS EC Number: 204-821-7
Chemical Formula: CH4N2O2
Molecular Weight: 76.05
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Suppliers: As per letterhead.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Germ cell mutagenicity Category 1A, 1B, H340
Reproductive toxicity Category 2 H361

Hazard statements:
H340 May cause genetic defects.
H361 Suspected of damaging fertility or the unborn child.

Precautionary statements:
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P308+313: IF exposed or concerned: Get medical advice/attention.
P405: Store locked up.
P501: Dispose of contents/container in accordance with local/regional/national/international regulation.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xn Harmful
Risk Phrase:
R46 May cause inheritable genetic damage.
R61 May cause harm to the unborn child.

Product Name/Trade Name: Hydroxyurea or Hydroxycarbamide.
CAS No.: 127-07-1
EINECS EC Number: 204-821-7

Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin: Immediately flush skin with plenty of water for at least 15 minutes. Remove and wash contaminated clothing and shoes before reuse. Get medical attention if irritation develops.
Eyes: Immediately flush eyes with plenty of water for 15 minutes, occasionally lifting upper and lower eyelids. Hold eyelids apart during irrigation. Get medical attention.
Inhalation: Remove person to fresh air. If breathing is difficult, give oxygen. If not breathing administer artificial respiration. Get medical attention.

Flash Point: N/A
Fire/Explosion: Not considered to be a fire and explosion hazard.
Extinguishing Medium: Water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Carbon oxides & Nitrogen oxides may evolve.
Fire Fighting Instructions: Use suitable protective equipment for surrounding fire.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment Cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Recommended storage temperature 2 - 8 °C

Exposure Limits: No data available.
Engineering Controls: Use adequate exhaust ventilation to keep airborne concentrations below the allowable exposure limit.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Dust deposits on floors and other surfaces may pick up moisture and cause the surfaces to become slippery and present safety hazards. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Physical State: Solid Powder.
Odor: None
Odor threshold: Not available.
pH: Not available.
Relative density: Not available.
Melting Point: 135C
Initial boiling point and boiling range: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility in water: Soluble in water.
Viscosity: Not available.
Chemical Formula: CH4N2O2
Molecular Weight: 76.05

Chemical Stability: Stable under recommended temperatures and pressures.
Incompatibility (Materials to Avoid): Oxidizing agents.
Conditions to Avoid: Incompatible materials, exposure to moist air or water, excessive heat.
Hazardous Decomposition Products: Carbon oxides, Nitrogen oxides.
Hazardous Polymerization: Will not occur.

Toxicity to Animals: LD50 Oral - Rat - 5,760 mg/kg for anhydrous material.
Carcinogenicity: IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Hydroxyurea).
Specific target organ toxicity: May cause damage to organs through prolonged or repeated exposure. Overexposure may cause reproductive disorder(s). May cause congenital malformation in the fetus. Suspected human reproductive toxicant. Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.

Ecotoxicity: No data available.
Persistence and Degradability: No information available.
Mobility: No information available.
Bioaccumulation/ Accumulation: No information available.
Results of PBT and vPvB assessment: No data available for assessment.
Environmental Precautions: DO NOT DISCHARGE into drains and rivers.

Dispose of in accordance with all applicable local, state, and federal regulations at an approved waste disposal facility.

DOT USA, TDG Canada & ADR/RID Europe: Not dangerous goods
IMDG/IMO: Not dangerous goods
IATA: Not dangerous goods.

USA:
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components: This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312: Chronic Health Hazard.
California Prop.65: WARNING! This product contains a chemical known to the State of California to cause birth defects or other reproductive harm. Hydroxyurea.

European Labeling in Accordance with EC Directives:
H340 May cause genetic defects.
H361 Suspected of damaging fertility or the unborn child.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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