Minoxidil IP BP EP Ph Eur USP Grade Manufacturers, with SDS GHS MSDS Sheet |
Supplier, Manufacturer, Exporter of Minoxidil, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc. The products are offered as per required specifications and in correct shape and size in mm or meshs or microns as specified by the buyer. The participating units have one or more accreditations like FDA - cGMP and GLP approval, ISO-9001 Certified, "REACH" Registered, ISO-14001, ISO/IEC 17025, ISO-22000, FSSC 22000, ISO 45001, Kosher Certified, Halal Certified, HACCP, FSSAI. We offer Commercial Pure & IP BP EP Ph Eur USP NF JP FCC Food Grade Analytical Reagent Grades of Chemicals |
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Minoxidil CAS Number 38304-91-5, EINECS EC Number: 253-874-2, Molecular Formula: C9H15N5O, Molecular Weight: 209.25, HS Code 29335995 or 29339990 or 29349990
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SDS MSDS Sheet of Minoxidil Manufacturers
Minoxidil
IP BP EP Ph Eur USP Grade Suppliers
Minoxidil or 2,4-Diamino-6-piperidinopyrimidine 3-oxide is a medication used for the treatment of high blood pressure and pattern hair loss. Minoxidil is an odorless, white to off-white, crystalline powder.
General Properties and Specifications of Minoxidil as per IP:
Appearance: White to off-white crystalline powder.
Odor: Odorless.
Identification:
By IR.
By UV.
By TLC.
Chemical Test.
Heavy metals: 20 ppm maximum.
Loss on drying: 0.5% maximum.
Sulfated ash: 0.1% maximum.
Related substances by HPLC: 1.5% maximum.
Residual solvents:
Methanol: 3000 ppm maximum.
Piperidine: 1000 ppm maximum.
Pyridine: 200 ppm maximum.
N-methyl pyrrolidone: 530 ppm maximum.
Ethylene dichloride: 5 ppm maximum.
Benzene: 2 ppm maximum.
Solubility: Slightly soluble in water. Soluble in methanol and in propylene glycol. Very slightly soluble in ether. Practically insoluble in chloroform and in acetone.
Melting Point: 248C.
Storage: Room temperature. Short term shipping may be ambient.
Minoxidil USP Grade Specifications:
C9H15N5O --- 209.25
2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide;
2,4-Diamino-6-piperidinopyrimidine 3-oxide CAS 38304-91-5
UNII: 5965120SH1
DEFINITION
Minoxidil contains NLT 97.0% and NMT 103.0% of minoxidil (C9H15N5O), calculated on the dried basis.
IDENTIFICATION
A. Infrared Absorption: Do not dry specimens.
Residue on Ignition: NMT 0.5%
Organic Impurities: NMT 1.5%
Loss on Drying: Dry a sample at 50C and at a pressure not exceeding 5 mm of mercury for 3 h. Acceptance criteria: NMT 0.5%
Packaging and Storage: Preserve in well-closed containers.
Minoxidil BP Ph Eur Grade Specifications:
C9H15N5O --- 209.3 CAS 38304-91-5
Action and use: Vasodilator; treatment of hypertension; male pattern baldness.
DEFINITION
6-(Piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide.
Content: 99.0 per cent to 101.0 per cent (dried substance).
CHARACTERS
Appearance: White or almost white, crystalline powder.
Solubility: Slightly soluble in water, soluble in methanol and in propylene glycol.
IDENTIFICATION
First identification: B
Second identification: A, C, D
A. Ultraviolet and visible absorption spectrophotometry.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.
D. Dissolve about 10 mg in 1 mL of methanol. Add 0.1 mL of copper sulfate solution. A green colour develops. The solution becomes greenish-yellow on the addition of 0.1 mL of dilute hydrochloric acid.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in an oven at 105C.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.
For Original Monographs of IP Indian Pharmacopoeia EP Ph Eur European Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.
We also manufacture and supply as under:
2-Phenyl-2-(Piperidin-2-yl) Acetamide
Manufacturers:
MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
Current Date Time in India GMT+5:30
e-mail: info@mubychem.com
USA, Canada, Mexico and other American
neighbouring buyers may
e-mail: us@mubychem.com
Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)
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Last
23 January, 2024
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Minoxidil SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 23-Dec-23
1. Product Identification
Product Name & Other Names: Minoxidil
CAS No.: 38304-91-5
EINECS EC Number: 253-874-2
Molecular Weight: 209.25
Chemical Formula: C9H15N5O
Relevant uses and uses advised against (if any) : Industrial Manufacturing.
Suppliers: As per letterhead.
2. Hazards Identification
GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, oral Category 4, H302
Skin corrosion/irritation Category 2, H315
Serious eye damage/eye irritation Category 2A, H319
Specific target organ toxicity, single exposure; Respiratory tract irritation Category 3, H335
Labeling according to Regulation (EC) No 1272/2008
GHS Label Elements  Irritant |
Signal Words: Warning
Hazard statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
P330: Rinse mouth.
P362: Take off contaminated clothing and wash before reuse.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P332+313: If skin irritation occurs: Get medical advice/attention.
P302+ P352 - IF ON SKIN: Wash with plenty of soap and water.
P305+ P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+313: If skin irritation occurs: Get medical advice/attention.
P337+P313 If eye irritation persists: Get medical advice/ attention.
P501: Dispose of contents/container to authorized agents only.
Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbols:
Xi Irritant
Xn Harmful.
Risk Phrases:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system, & skin.
3. Composition/Information on Ingredients
Product Name & Other Names: Minoxidil
CAS No.: 38304-91-5
EINECS EC Number: 253-874-2
4. First Aid Measures
Always get medical attention after the first aid is over.
Inhalation: Remove to fresh air. Give oxygen if breathing is difficult; give artificial respiration if breathing has stopped. Keep person warm and quiet; get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Immediately flush skin with plenty of soap and water for at least 15 minutes. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention.
5. Fire Fighting Measures
Fire: Not considered to be a fire hazard. May be combustible at high temperature.
Fire Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture: Toxic fumes, Carbon oxides, Nitrogen oxides (NOx) and Cyanides.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.
6. Accidental Release Measures
Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage: Do not inhale dust, vapors, mist, or gas. Avoid dust formation. Contain spilled material. Cover with an inert, non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate as per law.
7. Handling and Storage
Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. In case of insufficient ventilation, wear suitable respiratory equipment. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc.). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room temperature. Short term shipping may be ambient.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.
9. Physical and Chemical Properties
Appearance: White to off-white crystalline powder.
Odor: Odorless.
Odor threshold: Not applicable.
pH: Not available.
Relative density: Not available.
Melting point: 248C.
Boiling point: Not available.
Flash point: Not available.
Auto-ignition temperature: Not available.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Slightly soluble in water. Soluble in methanol and in propylene glycol. Very slightly soluble in ether. Practically insoluble in chloroform and in acetone.
Viscosity: Not available.
Molecular Weight: 209.25
Chemical Formula: C9H15N5O
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage. Forms explosive mixtures with air on intense heating. Fine distribution, when whirled up a dust explosion potential may generally be assumed.
Hazardous Decomposition Products: May produce toxic fumes, carbon oxides, nitrogen oxides (NOx) and cyanides when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Heat, flame, ignition sources, dusting, and incompatibles.
11. Toxicological Information
LD50 oral rat 1321 mg/kg.
Carcinogenic Effects: Not a reported carcinogen by IARC, NTP, ACGIH, OSHA.
Germ cell mutagenicity: Not available.
Reproductive toxicity: Not available.
Developmental Effects: Not available.
Teratogenicity: Not available.
12. Ecological Information
Toxicity: No data available.
Environmental Fate: No data available.
Persistence and degradability: No data available.
Mobility in soil: No data available.
Results of PBT and vPvB assessment: No data available.
Discharge into the environment must be avoided.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. Dispose of containers and unused material in accordance with legal requirements.
14. Transport Information
DOT USA, TDG Canada & ADR/RID Europe: Not regulated.
IATA: Not regulated.
IMDG/IMO: Not regulated.
15. Regulatory Information
USA:
SARA 311/312 Hazardous Categorization: Acute Health Hazard. See section 2.
California Proposition 65: This product does not contain any Proposition 65 chemicals.
16. Other Information
European Labeling in Accordance with EC Directives:
H302 = Harmful if swallowed.
H315 = Causes skin irritation.
H319 = Causes serious eye irritation.
H335 = May cause respiratory irritation.
Hazard Symbols:
Xi Irritant
Xn Harmful.
Risk Phrases:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system, & skin.
Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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