Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3 USP BP Ph Eur FCC Food Grade Manufacturers, with SDS GHS MSDS Sheet

Supplier, Manufacturer, Exporter of Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3, Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. Mubychem Group has several manufacturing facilities spread across Western India and world wide contacts and toll manufacturers. We are exporting globally to countries like USA, Canada, Europe, UAE, South Africa, Tanzania, Kenya, Egypt, Nigeria, Cameroon, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Dubai, Korea, Vietnam, Thailand, Malaysia, Indonesia, Australia, China, Germany, France, Italy, Portugal etc.

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Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3 CAS Number 98-92-0, EINECS EC Number: 202-713-4, Molecular Formula: C6H6N2O, Molecular Weight: 122.13, HS Code 29362920 or 29362900

Specifications, Safety Data Sheet, Manufacturing process details, Wholesale retail buy sell prices, Uses etc available on line in these pages for Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3.

Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3 is used as a dietary supplement and medication. It has also been used in many topical agents including sunscreens and cosmetic agents.

General Properties and Specifications of Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3:
Appearance: White crystalline powder.
Assay: 99.5% minimum.
Loss on drying: 0.2% maximum.
Heavy Metals (Pb): 0.003% maximum.
Nicotinic Acid: 0.2% maximum.
Suitability for Cell Culture: Passes test.
Bacterial Endotoxin Test (BET) (EU/mg = IU/mg): <0.05 EU/mg.
Relative density: about 1.40 @ 25C.
Auto-ignition temperature: 480C.
Melting Point: 128C - 131C.
Solubility: Soluble in water.
Storage: Room Temperature.

Niacinamide USP Grade Specifications:
C6H6N2O -- 122.12
3-Pyridinecarboxamide;
Nicotinamide CAS 98-92-0
UNII: 25X51I8RD4

DEFINITION
Niacinamide contains NLT 98.5% and NMT 101.5% of niacinamide (C6H6N2O), calculated on the dried basis.

Residue on Ignition: NMT 0.1%
Readily Carbonizable Substances:
Sample solution: Dissolve 200 mg of Niacinamide in 5 mL of sulfuric acid.
Acceptance criteria: The Sample solution has no more color than Matching Fluid A.
Melting Range or Temperature: 128C to 131C
Loss on Drying: Dry a sample over silica gel for 4 h: it loses NMT 0.5% of its weight.

DEFINITION
Pyridine-3-carboxamide.
Content: 99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Freely soluble in water and in anhydrous ethanol, slightly soluble in methylene chloride.

IDENTIFICATION
First identification: B.
Second identification: A, C
A. Melting point: 128C to 131C.
B. Infrared absorption spectrophotometry.
C. Thin-layer chromatography.

TESTS
Solution S: Dissolve 2.5 g in carbon dioxide-free water and dilute to 50 mL with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than.
pH: 6.0 to 7.5 for solution S.
Related substances: To pass the test.
Loss on drying: Maximum 0.5 per cent, determined on 1.000 g by drying in vacuo for 18 h.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Niacinamide FCC Food Grade Specifications:
Nicotinamide
C6H6N2O Formula weight 122.13
CAS 98-92-0

DESCRIPTION
Niacinamide occurs as a white, crystalline powder. One gram dissolves in about 1 mL of water, in about 1.5 mL of alcohol, and in about 10 mL of glycerin. Its solutions are neutral to litmus.
Function: Nutrient.

REQUIREMENTS
Identification:
A. Transfer about 20 mg of sample into a 1000-mL volumetric flask, dissolve in and dilute to volume with water, mix, and determine the absorbance of the solution in a 1-cm cell at 245 nm and at 262 nm with a suitable pectrophotometer, using water as the blank. The ratio A245/A262 is 0.65 _ 0.02.
B. The infrared absorption spectrum of a potassium bromide dispersion of the sample exhibits relative maxima at the same wavelengths as those of a similar preparation of USP Niacinamide Reference Standard.

Assay: Not less than 98.5% and not more than 101.0% of C6H6N2O after drying.
Lead: Not more than 2 mg/kg.
Loss on Drying: Not more than 0.5%.
Melting Range: Between 128C and 131C.
Readily Carbonizable Substances: Passes test.
Residue on Ignition: Not more than 0.1%.

For Original Monographs of IP Indian Pharmacopoeia BP British Pharmacopoeia USP US Pharmacopoeia FCC Food Grade product, please check with the respective web-pages or books.

MUBY CHEMICALS
Ambernath Mumbai, Ankleshwar Gujarat, India
TEL: (OFFICE) +912223770100, +912223726950
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Call toll-free 1-877-682-9243 (1-877-MUBYCHEM)

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Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3 SDS, Safety Data Sheet
MSDS Sheet, Material Safety Data Sheet 13-Sept-23

Product Name & Other Names: Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3.
CAS No.: 98-92-0
EINECS: EC Number: 202-713-4
Molecular Weight: 122.13
Molecular Formula: C6H6N2O
Relevant uses and uses advised against (if any): Industrial Manufacturing.
Supplier: As per letterhead above.

GHS, Globally Harmonized System Classification in accordance with 29 CFR 1910
Classification according to Regulation (EC) No 1272/2008

Precautionary statements:
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash skin thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352-IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/ attention.
P362: Take off contaminated clothing and wash before reuse.
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification according to EU Directives 67/548/EEC or 1999/45/EC:
Hazard Symbol:
Xi Irritant
Risk Phrases:
R36 Irritating to eyes skin.

Product Name & Other Names: Nicotinamide or Niacinamide or Nicotinic Amide or Pyridinecarboxamide or Vitamin B3.
CAS No.: 98-92-0
EINECS: EC Number: 202-713-4

Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Ingestion: Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Flammability of the Product: Combustible at high temperature.
Auto-Ignition Temperature: 480C literature.
Products of Combustion: Nitrogen oxides, Carbon dioxide, Carbon monoxide, fumes.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire. Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. At high temperatures under fire conditions, it may produce toxic or irritating fumes. Fire-extinguishing work is done from the windward and a suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place.

Personal precautions, protective equipment, and emergency procedures: Avoid breathing dust/fumes/gas/mist/vapors/spray. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Restrict unprotected personnel from the area. Prevent any contact with hot surfaces. Do not approach facing the wind. Do not touch the spilled material.
Environmental precautions: Do not let the product enter drains, soil, or water sources.
Methods and materials used for containment cleanup procedures and Storage:
Small Spill: Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
Large Spill: Contain spilled material. Avoid touching the spilled material. Do not let the product enter drains. Cover with an inert, non-combustible absorbent material, (e.g., sand, earth, diatomaceous earth, vermiculite). Use a shovel to put the material into a disposal container.

Precautions for safe handling: Apply according to good manufacturing and industrial hygiene practices. Ensure proper ventilation. Wash thoroughly after handling. Do not drink, eat, or smoke while handling. Do not ingest. Avoid contact with skin, eyes, and clothing. Minimize dust generation. Avoid breathing dust/fumes/gas/mist/vapors/spray. Keep container tightly closed. Avoid ingestion and inhalation. Use individual protective equipment (waterproof boots, suitable protective clothing, safety glasses, etc). Prevent any contact with hot surfaces.
Conditions for safe storage, including any incompatibilities: Store in cool, dry, and ventilated area away from heat sources and protected from sunlight in tightly closed original container. Keep air contact to a minimum. Do not leave the material container open. Store protected from heat, sparks and ignition sources and incompatible materials. Avoid contact with skin and eyes. Avoid inhalation of dust/mist/vapor. Do not store with incompatible materials like strong oxidizing agents. Storage: Room Temperature.

Airborne Exposure Limits: Not Established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved): For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Skin Protection: Wear protective gloves and clean body-covering clothing.
Eye Protection: Use chemical safety goggles and/or full-face shield where dusting or splashing of solutions is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Other Control Measures: Maintain good housekeeping in work area. Handle in accordance with good industrial hygiene and safety practice. Wash hands after handling.

Appearance: White crystalline powder.
Odor: Practically odorless.
Odor threshold: Not available.
pH: 6.0-7.5 @ 20C 5% for aq. solution.
Relative density: about 1.40 @ 25C.
Boiling Point: Not available.
Melting Point: 128C - 131C.
Flash point: Not available.
Auto-ignition temperature: 480C literature.
Decomposition temperature: Not available.
Upper/lower flammability or explosive limits: Not available.
Vapor pressure: Not available.
Vapor density: Not available.
Evaporation rate: Not available.
Flammability (solid, gas): Not available.
Partition coefficient: n-octanol/water: Not available.
Solubility: Soluble in water.
Viscosity: Not available.
Molecular Weight: 122.13
Molecular Formula: C6H6N2O

Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: It emits Oxides of Nitrogen, Carbon dioxide, Carbon monoxide & Fumes.
Hazardous Polymerization: Will not occur.
Incompatibilities: Strong oxidizing agents.
Conditions to Avoid: Incompatibles, heat & light, spark, flame.

Toxicity data
LD50 Oral - Rat - > 2500 mg/kg
LD50 Dermal - Rabbit - > 2,000 mg/kg
Carcinogenic Effects: Not know as carcinogen.
Mutagenic Effects: Not available.
Reproductive Effects: No information available.

Toxicity to fish: static test LC50 - Poecilia reticulata (guppy) - > 1.000 mg/l - 96 h.
Toxicity to daphnia and other aquatic invertebrates: static test EC50 - Daphnia magna (Water flea) - > 1.000 mg/l - 24 h.
Persistence and Degradability: Soluble in water Persistence is unlikely based on information available.
Mobility: Will likely be mobile in the environment due to its water solubility.
Bioaccumulation/ Accumulation: Degradable.
Results of PBT and vPvB assessment: No data available for assessment.

Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with law.

DOT USA, TDG Canada & ADR/RID Europe: Not regulated
IATA & IMDG/IMO: Not regulated.

USA:
SARA 311/312 Hazards: Immediate Health Hazard. See section 2.
California prop. 65: Contains no chemical subject to California Prop 65.

Disclaimer:
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Our company provides this MSDS sheet in good faith but makes no representation as to its comprehensiveness or accuracy. This SDS sheet is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. The above information has been compiled from various sources and has the possibility of discrepancy and being out-dated information. Individuals receiving the information must exercise their independent judgment and do further search in determining its appropriateness for a particular purpose. In no case shall our company be liable to loss or damages by the product user.
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